Showing 21 ideas for tag "cardiovascular"
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AoU Research Priorities Use Cases

How do maternal health complications affect the long-term health of women and outcomes in subsequent pregnancies?

Severe maternal morbidities are rare, but increasing in the U.S., and the causes and long-term consequences are poorly understood. All of Us would provide a study population with enough participants, detail, and follow-up time to thoroughly investigate how complications during pregnancy, delivery, and postpartum affect future health in women and their children to inform prevention of negative outcomes, such as cardiovascular... more »

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16 votes
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AoU Research Priorities Use Cases

The association of cardiovascular risk factors on the development of vascular dementia

Recent findings from 15,744 black and white adults in the ARIC Cohort Study found that several cardiovascular (CV) risk factors in middle age (smoking, diabetes, prehypertension & hypertension) are linked to higher risk of dementia later in life, and that blacks have higher rates of dementia v. whites. AoU offers ability to evaluate differential associations of specific CV risk factors, & their interactions with other... more »

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12 votes
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AoU Research Priorities Use Cases

Common trajectories of body mass index (BMI) across the lifespan and their differential impact on cardiovascular diseases

Following AoU participants for decades could uncover common trajectories of body mass index (BMI) across lifespan and their associations/impact on cardiovascular diseases (CVD). AoU’s size/diversity also enables precise measure of the associations by different subgroups (e.g., race, sex, social factors, presence of multiple risk factors). The findings could further shed light on optimal timing for initiating and/or intensifying... more »

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16 votes
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What are the impact of common environmental exposures on cardiovascular (CV) and other health outcomes?

We are constantly exposed to environmental exposures such as air pollution, allergens, and man-made chemicals. AoU offers a unique opportunity to collect such exposures both passively (e.g., linking to local environmental data) and actively (e.g., using novel mHealth devices to measure new data from individual AoU participants). These can be overlaid with behavioral, clinical, genomics, and biological data in AoU to assess... more »

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19 votes
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AoU Research Priorities Use Cases

Cytochrome P450 polymorphisms affect patient metabolism; would profiling CYP in large studies help predict patient outcomes?

Establish CYP profiling as a standard part of data collection in all large studies, especially related to pain management, immunology, cardiovascular dysfunction, pharmacology. Based upon existing research, it can be anticipated that CYP profiles and polymorphism data may partition certain studies' patient populations into groups with common outcomes (negative, positive, neutral.) Regarding the opioid crisis alone, CYP... more »

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16 votes
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How reliably do epigenetic aging clocks predict disease onset and mortality? Can they be slowed or reversed?

An annual blood test with analysis of methylation sites from key epigenetic aging clocks (e.g. Horvath). Epigenetic aging clocks have already been shown to reliably predict age, time-to-death, all cause mortality, cog. function, immune function, CV disease, cancer, and more. They may also become a key tool to demonstrate the reversibility of disease risk through dietary and therapeutic regimens, as epigenetic states are... more »

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35 votes
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