Showing 19 ideas for tag "chronic-disease"
(@nichd.allofus) kudos icon +

AoU Research Priorities Use Cases

How are sleep characteristics associated with pediatric developmental conditions, disorders or chronic disease?

This study will focus on the entire cohort (infant-19 y/o) to provide health and behavior outcomes associated with sleep characteristics, including environmental and demographic factors. This information will help better define the development of sleep, help develop more precise strategies to target children with sleep characteristics predictive of poor health outcomes, and develop more precise strategies for children... more »

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94 votes
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(@edenberg) kudos icon +

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The effects of alcohol (and other drug) consumption on major somatic diseases and psychiatric disorders and their treatments.

Alcohol affects nearly all major diseases. Failing to capture lifetime alcohol exposure will adversely affect the goals of All of Us.

There are better questions about consumption, that should be asked of previous year, typical year and heaviest year.

Questions should be asked about problems due to alcohol, and those should be focused on lifetime.

Additional questions about other drugs should also be included.

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61 votes
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(@qtnguyen) kudos icon +

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What neighborhood conditions promote health?

This project would examine contextual factors that may influence the health outcomes of individuals. Contextual factors include social environment factors (such as social cohesion, crime) and built environment factors (green space, mixed land use, access to healthy food and clinical services). These factors can help or hinder individuals from achieving or maintaining health. Outcomes of interest include obesity, diabetes,... more »

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45 votes
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(@rebeheart) kudos icon +

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What are the longterm health effects of adverse childhood experiences in racial/ethnic minority populations?

Adverse childhood experiences (ACE; abuse, neglect) are not uncommon and are associated with increased risk of developing a range of chronic diseases in adulthood (e.g., cardiovascular, cancer, etc.). This has mainly been studied in white middle-class populations. Less is known whether ACEs similarly impact racial/ethnic minorities. Cross-sectional design with retrospective ACE report and longitudinal design for long-term... more »

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47 votes
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(@pfuller) kudos icon +

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Wearables for capturing sleep and circadian information across day/night and long-term.

Wearables that can capture sleep and circadian information-across the day/night and over time--should be included. Activity monitors, EEG, ECG and Oximetry measurement are increasingly accessible with miniaturization of technology. Consumer interest in many of these devices has accelerated development and driven costs down. Analysis of these data-perhaps using open-platforms- hold promise for deriving quantitative measurements... more »

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84 votes
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(@jaime.hart) kudos icon +

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How do exposures to multiple environmental stressors impact chronic disease risk

The goal would be to examine the associations between multiple environmental stressors (air pollutants, temperature, etc) on chronic disease risk, and how these associations are modified by inherent characteristics, lifestyle factors, and the built and natural environments. This would require current & historical residential/work addresses and appending environmental data. This would provide more information on how these... more »

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27 votes
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(@evogtmann) kudos icon +

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Is the human oral and fecal microbiota associated with chronic disease risk factors, such as obesity and metabolic syndrome?

The human microbiota has been found to be associated with a number of health conditions, such as obesity. However, these studies have been relatively small and from convenience samples. It is important to understand how the human microbiota impacts these chronic disease risk factors in order to prevent future disease development. We propose collecting oral and fecal samples to determine associations with many chronic... more »

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28 votes
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How do experiences of racial discrimination relate to HPA axis activity and the prevalence of chronic illnesses?

Instances of racial discrimination activate the HPA axis, and this chronic activation may be related to the disproportionate prevalence of chronic illnesses in members of racial minority groups. Some studies have found a blunted cortisol concentration in African Americans, compared to Caucasians. However, it's unknown whether all members of racial minority groups have a blunted cortisol concentration, and how it relates... more »

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17 votes
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(@rebeheart) kudos icon +

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Develop a Social-Determinants-of-Health risk calculator for chronic disease development (cardiovascular, Type 2 Diabetes, etc)

Which social determinants of health (SDH) or what combination carry the greatest risk for the development of top chronic diseases?Developing a SDH risk calculator can guide clinical practice, community resource allocation, and prevention efforts. Use evidence-based SDH variables to develop a predictive model for 10yr risk of developing most common chronic diseases. Test model in a diverse sample <18 years of age over... more »

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22 votes
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(@riscutag2) kudos icon +

AoU Research Priorities Use Cases

Evaluate Age-related Microbiota Changes and their impact in Health, and in Chronic Disease Prevention, Treatment and Progression

The microbiome variations have been associated with health and disease status in cross-sectional studies. There is a need to examine these associations in a longitudinal fashion and to establish baseline changes in health and disease over a lifespan. All of Us Together provides a game-changing amount of longitudinal data on enough individuals to begin to map the complex relationship between exposures (diet, antibiotics,... more »

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19 votes
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(@troianor) kudos icon +

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How are sleep, sedentary behavior and physical activity related to one another, and interactively, related to health?

Sleep (quantity, quality, timing), sedentary behavior, and physical activity of various intensities, affect each other and many health outcomes. Health conditions affect individuals’ sleep and activity patterns. Capturing 24-hour device data repeatedly will allow exploration of multiple hypotheses about sleep, sedentary behavior, physical activity and health. Longitudinal data will allow exploration of causality in both... more »

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27 votes
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(@niehsextramural) kudos icon +

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How environmental chemicals mediate/influence comorbid chronic diseases?

Two of the greatest public health challenges facing the US today are obesity and asthma. These two comorbid conditions are also implicated in downstream disorders such as diabetes and CVD. There is evidence that environmental exposures contribute to a rapid increase in disease incidence. Using the AoU cohort to understand how environmental exposures exacerbate the cormbidity between these conditions and subsequent disease... more »

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15 votes
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(@zoradjuric) kudos icon +

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Does weight gain negate the beneficial effects of eating healthy foods?

Adult weight gain and obesity increase risks of chronic diseases. The effects of a positive energy balance could outweigh any beneficial effects of foods associated with reduced health risks such as vegetables, whole grains and omega-3 fatty acids. In subsets of adults who are either gaining weight or maintaining weight over time, does the impact of diet quality on health risks differ? Diet could be quantified by various... more »

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10 votes
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