Two of the greatest public health challenges facing the US today are obesity and asthma. These two comorbid conditions are also implicated in downstream disorders such as diabetes and CVD. There is evidence that environmental exposures contribute to a rapid increase in disease incidence. Using the AoU cohort to understand how environmental exposures exacerbate the cormbidity between these conditions and subsequent disease... more »

More than 1 in 5 Americans meet lifetime criteria for alcohol use disorder and 1 in 10 Americans meet lifetime criteria for a drug use disorder. Most individuals never seek treatment and most reduce their alcohol or drug use in the absence of treatment. Research on the biological, psychological, and social risk factors for developing and recovering from alcohol/drug use disorders is critical. Annual assessments of DNAm,... more »