Showing 11 ideas for tag "diabetes"
(@niehsextramural) kudos icon +

AoU Research Priorities Use Cases

How environmental chemicals mediate/influence comorbid chronic diseases?

Two of the greatest public health challenges facing the US today are obesity and asthma. These two comorbid conditions are also implicated in downstream disorders such as diabetes and CVD. There is evidence that environmental exposures contribute to a rapid increase in disease incidence. Using the AoU cohort to understand how environmental exposures exacerbate the cormbidity between these conditions and subsequent disease... more »

Voting

15 votes
Ideate
(@niehsextramural) kudos icon +

AoU Research Priorities Use Cases

The AoU Exposome Study: Untargeted Discovery of environment-disease associations

The exposome has been defined as the totality of environmental exposures throughout the life-course. Regardless of the definition it is as a tool for the untargeted hypothesis free discovery of associations between environmental exposures and disease outcomes. This is best applied to high prevalence phenotypes that are likely to occur in the cohort such as the conversion of metabolic syndrome to overt diabetes where it... more »

Voting

14 votes
Ideate
(@esl000) kudos icon +

AoU Research Priorities Use Cases

What are the genetic biomarkers/factors that confer risk for development and progression of diabetic retinopathy?

Submitted by: NEI Collaborative Clinical Research Program Officers

Diabetes often leads to end-organ complications, one of which is diabetic retinopathy and vision loss. This has a significant impact on quality of life for the diabetic patient. Finding genetic determinants would be predictive for this outcome within the diabetic population and may potentially lead to therapeutic interventions.

Voting

8 votes
Ideate
(@tlzjones) kudos icon +

AoU Research Priorities Use Cases

Do specific diabetes drugs increase the risk of peripheral artery disease, a diabetic foot ulcer or an amputation?

A major advance in diabetes treatment is the finding that specific glucose-lowering drugs reduce the risk of cardiovascular disease. The results were tempered by the increased risk of amputations for the groups that received the SGLT2 inhibitor, canagliflozin. The generalizability of this finding is unknown. An understanding of the association of specific diabetes drugs with lower extremity complications will allow... more »

Voting

10 votes
Ideate

AoU Research Priorities Use Cases

What factors are associated with albuminuric and non-albuminuric diabetic kidney disease, and with the eGFR reduction over time?

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD), the most serious and expensive stage of chronic kidney disease (CKD). Pre-ESRD stages of CKD are also associated with significant health care burden. DKD can progress to ESRD with or without albuminuria. Better understanding of risk factors attributable to the development of albuminuric and non-albuminuric DKD, and to their progression... more »

Voting

8 votes
Ideate
(@dmarriot) kudos icon +

AoU Research Priorities Use Cases

Treatments to reduce risk of stroke following a transient ischemic attack (TIA)

Transient ischemic attack (TIA) is a frequent precursor to stroke. Studies of modern treatments (e.g., carotid endarterectomy and carotid artery stenting) do not consider TIA as an indicator for treatment, nor which treatments may be more effective following a TIA. All of Us provides a unique opportunity to not only examine the interaction between TIA and treatment to prevent subsequent strokes, but also to suggest... more »

Voting

4 votes
Ideate
(@wye000) kudos icon +

AoU Research Priorities Use Cases

What is the long-term comparative effectiveness of empagliflozin in a heterogeneous population with type 2 diabetes?

Empaglifozin, a highly selective sodium-glucose cotransport 2 (SGLT2) inhibitor, has been shown to significantly reduce major adverse cardiovascular (CV) events and hospitalization for heart failure in patients with type 2 diabetes (T2DM) and established CV disease. The generalizability of this finding to lower risk population is unknown. We propose to compare cardiovascular outcomes in a more heterogeneous population... more »

Voting

3 votes
Ideate
(@carolinep) kudos icon +

AoU Research Priorities Use Cases

Are the risk factors of friction/shear forces being adequately addressed in people with Diabetes, to protect skin integrity?

Diabetes places people at risk for problems with skin integrity, and complications that can risk the patient's limbs and life. Friction and shear forces are known extrinsic factors in pressure injuries and diabetic foot wounds, but this is not consistently addressed as part of the treatment plan. This can contribute to complications, and a higher cost of care. Better understanding of this gap in treatment may allow increased... more »

Voting

1 vote
Ideate
(@carolinechen) kudos icon +

AoU Research Priorities Use Cases

Is there a correlation between different transit mode use and bmi?

Goal: To determine whether transit mode choice and travel time is associated with bmi and health status
Identify 3 neighborhoods with similar avg incomes, but different transport options
Select a random sample of households from each neighborhood.
One adult provides info on transit choice, travel time, destination distance, bmi and health status.
Expected outcome: Among similar income levels, adults who drive less have... more »

Voting

1 vote
Ideate
kudos icon +

AoU Research Priorities Use Cases

AoU’s sample/measures uniquely allow for modeling high-burden disease pathways specified by the biopsychosocial ecological model

Biological, psychological & social domains interact at multiple levels (genes, human & environment microbiomes, stress, behavior, broad SES & environment) outlined by the biopsychosocial ecological model (BPSEM). The BPSEM specifies pathways aligned with the AoU pillars of biology, lifestyle, & environment. Simultaneous examination of the interacting domains and levels of the BPSEM is now computationally possible and... more »

Voting

1 vote
Ideate