Showing 21 ideas for tag "environmental"
(@nichd.allofus) kudos icon +

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What are the genetic and environmental risk factors that contribute to the broader autism phenotype in adolescents and adults?

To study genotype-phenotype correlations, utilize measures targeting the Broader Autism Phenotype: social and communication scales (SRS), Connors Rating Scale for ADHD, ratings of depressive symptoms (PHQ-9), anxiety disorders, & adverse childhood experiences (ACEs) & traumatic life events. Children transitioning to adulthood during the study will have repeat assessment of function and mental health status at a later... more »

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42 votes
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(@mpollard) kudos icon +

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Criteria for Environmental Associated Autoimmune Diseases

Goal: Survey patients with autoimmune diseases for information on occupational and other life style exposures to factors associated with autoimmunity (smoking, silica dust, solvents, etc). Build data bases containing clinical parameters, blood tests, and exposure data to help identify putative diagnostic criteria. Compare with patients having idiopathic autoimmunity (i.e. lacking known risk exposures)

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55 votes
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(@klosecall) kudos icon +

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Can pollen allergies be isolated by genetics, confirmed by allergy testing, and exposure be tracked to limit asthma attacks?

A cohort of asthma patients (who believe they have a pollen allergy) would undergo genetic testing to identify genetic markers. Those patients would undergo blood and skin allergy testing to confirm the allergy, and then the patients would be utilize a mobile monitor to track the weather and environmental exposures (esp. pollen) that are causal to asthma incidences. With a more complete picture of pollen allergen impacts... more »

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39 votes
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(@nichd.allofus) kudos icon +

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What factors are involved in loss of fecundity in males and females?

This study will focus on the entire cohort across the reproductive lifespan (ages 12-55) collecting data on fertility (time to conception) and pregnancy loss. Additional data will include factors believed to be indicators of fertility as determined by questionnaire, blood tests, factors believed to negatively impact fertility, and genetic/epigenetic data that together may provide new targets for understanding oocyte depletion,... more »

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29 votes
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(@alan.sanders.md) kudos icon +

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Which genetic and environmental factors contribute to sexual orientation, and related health conditions?

Gays, lesbians, and bisexuals are underrepresented in biomedical research. While much relevant data is already planned for collection by AllofUs, additional or elaborated measures (see "data items") would help in seeking new leads and advancing work on pre-existing questions in the field. These items include sociodemographic (e.g., trait information), clinical (various associated conditions), and biological (genomic,... more »

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30 votes
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(@jaime.hart) kudos icon +

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How do exposures to multiple environmental stressors impact chronic disease risk

The goal would be to examine the associations between multiple environmental stressors (air pollutants, temperature, etc) on chronic disease risk, and how these associations are modified by inherent characteristics, lifestyle factors, and the built and natural environments. This would require current & historical residential/work addresses and appending environmental data. This would provide more information on how these... more »

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27 votes
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Preconception predictors of preterm birth

Given the limited effects of current interventions to prevent preterm birth, it seems likely that the stage for adverse pregnancy outcomes is set even before the pregnancy begins. The All of Us cohort, if sufficient reproductive-aged women are enrolled, would be in a position to examine social, behavioral, medical, and biological/molecular predictors of preterm birth and its subtypes.

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17 votes
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(@ginawei) kudos icon +

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What are the impact of common environmental exposures on cardiovascular (CV) and other health outcomes?

We are constantly exposed to environmental exposures such as air pollution, allergens, and man-made chemicals. AoU offers a unique opportunity to collect such exposures both passively (e.g., linking to local environmental data) and actively (e.g., using novel mHealth devices to measure new data from individual AoU participants). These can be overlaid with behavioral, clinical, genomics, and biological data in AoU to assess... more »

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19 votes
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(@pinneysm) kudos icon +

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What is the the population shift in prevalence of chronic disease with past environmental exposures (esp in older persons)

Careful and extensive characterization of lifetime environmental exposures and chronic disease phenotypes in the All of Us population; determination of genetic risk factors for various exposure and disease combinations; follow-up for chronic disease outcomes.

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10 votes
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(@niehsextramural) kudos icon +

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How environmental chemicals mediate/influence comorbid chronic diseases?

Two of the greatest public health challenges facing the US today are obesity and asthma. These two comorbid conditions are also implicated in downstream disorders such as diabetes and CVD. There is evidence that environmental exposures contribute to a rapid increase in disease incidence. Using the AoU cohort to understand how environmental exposures exacerbate the cormbidity between these conditions and subsequent disease... more »

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15 votes
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(@mnorena) kudos icon +

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Environmental Exposures in the Ohio-Mississippi River Basin: The Missing Link to Obesity

I think the root cause of the obesity epidemics in the Mid-South USA is linked to the NUTRIENT POLLUTION OF THE OHIO-MISSISSIPPI RIVER BASIN, in particular the run off of agricultural fertilizers (nutrient enrichment). These rivers run across the states most affected by obesity. I recommend to measure environmental exposures - chemical (i.e. phosphorus) and biological toxins (i.e. microsystin, cyanotoxins) and measure... more »

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11 votes
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(@atrenthamd) kudos icon +

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Exposures to environmental chemicals during pregnancy and effects on epigenetic biomarkers of metabolic syndrome and obesity

Obesity and breast cancer are leading cause of morbidity and mortality. Evidence strongly suggests that certain periods of life, including those during fetal development and pregnancy, influence risk of breast cancer later in life. Environmental chemicals may increase breast cancer risk-especially during pregnancy-by mimicking estrogen and other hormones. Epigenomic signatures present in the placenta uniquely capture... more »

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9 votes
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