Showing 21 ideas for tag "environmental"
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Is mammographic breast density causally related to breast cancer and/or an intermediate risk factor for breast cancer?

Breast cancer is the most common cancer in US women. Breast density, usually measured from mammograms, is a strong risk factor for breast cancer and is correlated with many other risk factors, but it is unknown whether changes in breast density reflect changes in breast cancer risk. Importantly, breast density provides a measure of breast cancer risk during menopause when endogenous hormone levels are changing and breast... more »

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8 votes
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(@jpcastner15) kudos icon +

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What are the multi-level, environmental exposure endotype pathways of autoimmune inflammation and disease? Reactive airway?

Focusing recruitment on communities with a disproportionate burden of environmental exposures, develop and test a multi-level model to ascertain the burden of autoimmune inflammation, autoimmune disease, and reactive airway attributable to environmental factors at the 1) community/neighborhood, 2) household, 3) personal, 4) internal body burden, and 5) inflammatory biomarker response levels over time. Ascertain how genetic... more »

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7 votes
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What are the health effects of sustained ambient exposure above state/fed health-based annual guideline concentrations?

For communities that have sustained (1+ years) ambient and community exposure levels above EPA and/or state environmental agency health-based annual guideline concentrations (e.g. US vs. Tonawanda Coke 10-CR-219-S with increased residential neighborhood levels of PAH's and aldehydes). For these communities seeking research on the increased relative risk of rare disease outcomes, like leukemia, best served by the scale... more »

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4 votes
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(@brodyj) kudos icon +

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Does exposure to environmental chemicals, such as PFAS, affect incidence of autoimmune disease in young adults?

By prospectively assessing exposures to environmental chemicals, such as per- and polyfluoroalkyl substances (PFAS), All of Us could evaluate whether these exposures are contributing to the rising incidence of autoimmune diseases in young adults. Intermediate biological outcomes related to thyroid function, inflammation, and immune response could be assessed.

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5 votes
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What are the best ways to report back to participants on biomarkers for environmental chemicals?

All of Us has committed to reporting back to participants on their biomarkers. The study can advance methods for reporting on environmental chemicals in the context of genetic data and health by studying the experiences of All of Us participants, including how they view and use their reports, their cognitive and emotional responses, and other outcomes.

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5 votes
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Does exposure to endocrine disrupting compounds (EDCs) influence the effectiveness of treatments for hormonal cancers?

EDCs are widespread in consumer products, air, and drinking water. Cancer treatments (such as tamoxifen and aromatase inhibitors for breast cancers) depend on altering the body's hormone levels. All of Us could evaluate whether EDCs interfere with cancer treatments. This study would involve assessing EDC exposure in patients during treatment and evaluating hormonal outcomes and disease progression outcomes.

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2 votes
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