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AoU Research Priorities Use Cases

The AoU Exposome Study: Untargeted Discovery of environment-disease associations

The exposome has been defined as the totality of environmental exposures throughout the life-course. Regardless of the definition it is as a tool for the untargeted hypothesis free discovery of associations between environmental exposures and disease outcomes. This is best applied to high prevalence phenotypes that are likely to occur in the cohort such as the conversion of metabolic syndrome to overt diabetes where it... more »

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AoU Research Priorities Use Cases

What are the associations between the exposome and health?

To understand health effects of the exposome, exposure assessment in population-based research should include measures of all the exposures of an individual in a lifetime, including general external, specific external, and internal. Assessing the exposome requires multiple, repeated longitudinal and hierarchical exposure measurements with sufficient variability; standardized methodology and analysis; and capabilities... more »

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