Cardiovascular disease and depression are associated, but direction is unclear - or both (heart attack is a stressor triggering depression, depression leads to less exercise and increases CVD). Sleep disturbance is associated with alcohol and depression - cause and effect unclear. Alcohol can increase depression risk, and vice versa. Increasing omega-3 vs. omega-6 may be preventive for both depression and CVD. AOU is... more »

Careful and extensive characterization of lifetime environmental exposures and chronic disease phenotypes in the All of Us population; determination of genetic risk factors for various exposure and disease combinations; follow-up for chronic disease outcomes.

Focusing recruitment on communities with a disproportionate burden of environmental exposure (such as Western New York), develop and test a multi-level model to ascertain the burden of environmental illness symptom clusters, asthma, and allergies attributable to environmental factors at the 1) community/neighborhood, 2) household, 3) personal, 4) internal body burden 5) inflammatory biomarker response levels over time.... more »

Focusing recruitment on communities with a disproportionate burden of environmental exposures, develop and test a multi-level model to ascertain the burden of autoimmune inflammation, autoimmune disease, and reactive airway attributable to environmental factors at the 1) community/neighborhood, 2) household, 3) personal, 4) internal body burden, and 5) inflammatory biomarker response levels over time. Ascertain how genetic... more »

Complex diseases are a result of a complex interplay of genetic, environmental, host and societal factors operating over a prolonged time. Many factors associated with disease onset or progression have been elucidated using a silo-ed approach which fails to adequately assess interplay between factors. Longitudinal measures and more sophisticated analytical methods are needed to support comprehensive (e.g. systems or computational... more »

Acute exacerbation accounts for frequent and recurrent ER visits in children with asthma. Genetic susceptibility and interaction with factors such as infection/inflammation, exposure to environmental pollutants may contribute to acute decompensation. Predictive modeling using multiple data points including genetic variants, environmental exposure, and self monitored spirometry may help with early detection and intervention... more »