Showing 2 ideas for tag "high-risk"
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AoU Research Priorities Use Cases

Longitudinal changes in sensory sensitivity

Understand how sensory sensitivity precedes development of chronic pain or sensitivity states (like itch bloating). Prospective study with smart phones repeated assessments of pain and symptom self-report (similar to PROMIS). Also include measures of visceral unpleasantness (nausea, photophobia, bloating). Determine if mood and neurological diagnose,, pregnancy, history of trauma, neighborhood, diet, social support,... more »

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(@nhgri.divisionofgenomescience) kudos icon +

AoU Research Priorities Use Cases

What happens to people before and as they come down with a disease? How do high-risk people who don't get the disease differ?

We can identify people who are at high risk for many diseases. However, not all high-risk people develop the disease. This study would follow people in high-risk groups longitudinally and identify specific genomic, physiological, clinical, and exposure factors that are either predictive or protective of transition to disease. This should focus on a diverse set of people (ethnicity, gender/sex, age, SES, rural/urban,... more »

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