Showing 2 ideas for tag "mechanisms"
(@rebeheart) kudos icon +

AoU Research Priorities Use Cases

Are different depression phenotypes associated with different prognosis after myocardial infarction (MI)?

Are there depression (MDD) phenotypes that have different genomic, biological, and psychological underpinnings, which we should be treating differently? Utilize an acute post-MI sample stratified by non-MDD, prior history of MDD, or new MDD. Then stratify all MDD by treated-success-MDD, treatment-resistant depression, and not treated. Examine mortality and cardiovascular event recurrence among non-MDD and MDD types,... more »

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(@pgreen00) kudos icon +

AoU Research Priorities Use Cases

Do systemic therapies used for cure or control of diseases like cancer, HIV, or diabetes alter aging phenotypes?

Clinical evidence suggests that cancer survivors, people living with HIV/AIDS, and diabetics may age prematurely from treatment toxicity. The All of Us study could be used to study these observatons over time by comparing aging trajectories and risk factors for individuals with and without systemic therapy use and investigate the mechanisms that cause alterations in the rate or way individuals age.

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