AoU Research Priorities Use Cases
AoU Research Priorities Use Cases
What is the functional mechanism when environmental exposures are associated with human health effects? Vary by age of exposure?
Using biospecimens of persons of varying ages, characterize exposure to environmental chemicals and metals over time and conduct omics studies to identify the functional mechanism of observed health effects - gene expression, metabolomics, epigenetics and genetic variants. Most important, have a plan for integrating the findings of these various studies.
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AoU Research Priorities Use Cases
Can metabolite profiles improve disease prediction and management?
The window of opportunity for disease prevention in at-risk individuals may be before symptoms occur and blood/urine chemistries indicate a problem. Considering that one’s metabolome reflects both genetic and environmental influences, could metabolite profiles be explored in the All of Us biospecimens and assessed as diagnostic tools?
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AoU Research Priorities Use Cases
What are the molecular subtypes of hypertension?
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AoU Research Priorities Use Cases
Changes involved in the progression of T2D and development of complications is apparent at the pre-DM state or during the transi
Changes involved in the progression of T2D and development of complications is apparent at the pre-DM state or during the transition to T2D or with complications. Conducting ‘Omics’ including DNA methylation, metabolomics and microbiome studies in blood, saliva and Fecal samples allows to validate interactions of metabolites to microbiota to epigenetic regulations.
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AoU Research Priorities Use Cases