AoU Research Priorities Use Cases
AoU Research Priorities Use Cases
What characteristics distinguish a healthy maternal pregnancy-microbiome from one that experienced microbial perturbations?
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AoU Research Priorities Use Cases
What microbiome characteristics of children exposed to antibiotics and different diets influence long-term health outcomes?
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AoU Research Priorities Use Cases
What is the impact of fluid intake on health?
There is a fluid intake range that is healthy. Below this level predisposes to urinary tract infections, urinary stone formation, changes in the gut and urinary micro biome, and results in generalized symptoms of well-being. Fluid intake above a healthy threshold predisposes to lower urinary tract symptoms, sleep interruptions and may affect symptoms of well-being.
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AoU Research Priorities Use Cases
Could the Precision Medicine Initiative Reduce Social Inequality?
Working with systemic malodor/PATM community provides unprecedented opportunities to explore biomarkers of depression, social stress, diabetes, inflammatory diseases, dental, cardiovascular, and digestive health, exposure to antibiotics, lifestyle & dietary... more »
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AoU Research Priorities Use Cases
How can we translate knowledge about the microbiome into better ways to diagnose and treat autoimmune diseases?
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AoU Research Priorities Use Cases
Is the human oral and fecal microbiota associated with chronic disease risk factors, such as obesity and metabolic syndrome?
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AoU Research Priorities Use Cases
Using human microbiome data to improve pathogenesis and treatment of infectious diseases
Specific research questions re pathogenesis and treatment:
- What aspects of the indigenous microbiota mediate colonization resistance against C. difficile, as well as other multi-drug resistant organisms such as carbapenamase-producing gram negative bacteria and vancomycin resistant... more »
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AoU Research Priorities Use Cases
How can AoU data be harnessed to improve infectious diseases patient care, diagnostics, vaccinolology, and drug development?
How is precision medicine as it applies to infectious diseases different than how it is considered for Oncology or other fields?
• Time-pressured setting (e.g., initiating therapy for a hospital acquired or ventilator-associated bacterial pneumonia patient)
• Microbiome vs. human genome
• Intersections with other cognitive and procedural specialties across the board
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AoU Research Priorities Use Cases
Evaluate Age-related Microbiota Changes and their impact in Health, and in Chronic Disease Prevention, Treatment and Progression
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AoU Research Priorities Use Cases
Can we develop a protocol to assess for Leaky Gut self help regimen to follow to heal the gut and establish a healtjy gut
1. Questionaire to assess for Leaky Gut.
2. Lab tests to assess for abnormal Intestinal flora.
3. Serum lab tests to assess for inflamation in body.
4. Dietary and nutritional supplement protocol to follow to establish healthy gut microbiome.
5. Correlate positive leaky gut diagnosis with other medical disorders present in the subject.
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AoU Research Priorities Use Cases
Could adding fecal sampling to the "All of Us" campaign help resolve role of gut microbiome in complex disease risk?
The simple addition of fecal sample for the use of gut microbiome taxonomical assessment could prove a valuable resource for testing hypotheses about the gut flora as a target of, and contributor to myriad human health and disease states. Fecal sample collection is non-invasive and gut bacterial lab methods are becoming increasingly refined and high-throughput.
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AoU Research Priorities Use Cases
Dietary and microbial-derived metabolites may modulate body weight and contribute to overweight and obesity.
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AoU Research Priorities Use Cases
Investigate whether ethanol consumption facilitates absorption of carcinogenic products from oral microbiome constituents.
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AoU Research Priorities Use Cases