Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders, affecting approximately 1 in 2,500 people in the United States. Since 1991, 90 different genes causing CMT subtypes have been identified, but the severity of the disease can vary even among families with the same genetic variant. Disease-modifying genes, epigenetics, mitochondrial involvement, exercise levels, diet, and environmental... more »

A major advance in diabetes treatment is the finding that specific glucose-lowering drugs reduce the risk of cardiovascular disease. The results were tempered by the increased risk of amputations for the groups that received the SGLT2 inhibitor, canagliflozin. The generalizability of this finding is unknown. An understanding of the association of specific diabetes drugs with lower extremity complications will allow... more »

Peripheral neuropathy is common in persons with diabetes and those over 40, and can be measured with validated claims data. The main disease risk factors, other than hyperglycemia, are unknown. We propose a first in kind study to simultaneously address how behavioral (diet, exercise, sleep), environmental (air quality, food access), and genetic factors influence the development of neuropathy and whether these factors... more »