Showing 3 ideas for tag "overactive"
(@arianasmith) kudos icon +

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In Overactive Bladder does pharmacogenomics influence individual response to antimuscarinic and beta-agonist bladder medication?

Overactive bladder is highly prevalent with significant impact on quality of life. Medications are utilized despite variable efficacy, high side effect burden, and poor persistence on therapy. This study will identify an overactive bladder cohort who have been prescribed antimuscarinic or beta-agonist medication to relieve symptoms. We hypothesize relief of symptoms will be based on the individuals pharmacogenomics. Personalized... more »

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(@hhenrylai) kudos icon +

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What are the biological, behavioral and metabolic factors that predict response vs non-response to overactive bladder treatment?

One out of 6 adults in the US (33 millions) and one out of 10 worldwide (546 millions) are affected by overactive bladder (OAB). Despite the high economic cost ($82 billions by 2020), treatment response to OAB remains suboptimal. Using data from over 1 million men and women, we will identify biological (eg, genomics, ethnicity, medical history), behavioral (lifestyle), and metabolic factors (eg, metabolic syndrome, obesity)... more »

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(@diane.newman) kudos icon +

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What factors predict response to lifestyle modification & bladder training in adults with symptoms of overactive bladder (OAB)?

Lifestyle (eg, diet) modification & bladder retraining (LMBR) are effective for many but not all persons with OAB symptoms (urinary urgency, frequency + incontinence). We will identify determinants of successful LMBR in a prospective cohort of adults with OAB symptoms treated with LMBR by comparing hypothesized moderators of LMBR spanning medical and social ecological models (eg, self-efficacy, race, occupation, SES,... more »

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