AoU Research Priorities Use Cases
AoU Research Priorities Use Cases
What is the population genetics of genes that code for drug-metabolizing enzymes? Do any correlate with drug reactions?
2) Describe the population genetics of these specific genes. How many people are normal (extensive metabolizers, EMs)? How many have other profiles? How many genes is the "average person" abnormal for?
3) By collecting data for "allergies" (some of which are intolerances, not true allergies) and medication reactions requiring... more »
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AoU Research Priorities Use Cases
Cytochrome P450 polymorphisms affect patient metabolism; would profiling CYP in large studies help predict patient outcomes?
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AoU Research Priorities Use Cases
Can we establish a data base for pharmacogenimcs based on ethnicity ,for a more feasible precision medicine ?
We all aspire for precision Medicine particularly when it comes to response to drugs , pharmacogenomics , cancer treatment or heart disease , yet logistic and economical barriers still keep this far from universal application.
The proposed study would answer if precision medicine practice based on Ethnicity is appropriate or not.
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AoU Research Priorities Use Cases
In Overactive Bladder does pharmacogenomics influence individual response to antimuscarinic and beta-agonist bladder medication?
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AoU Research Priorities Use Cases
What GENE(S) is responsible for HYPERSENSITIVITY to inhaled corticosteroids in Asthma patients, and how does it function?
2) Determine... more »
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AoU Research Priorities Use Cases
What risk factors predispose patients treated for pain to misuse or abuse prescription drugs?
Conduct a RCT to explore genetic and environmental risk factors associated with dose escalation leading to misuse or abuse of prescribed opioids. Use EHR and PDMP data to capture patient demographic, history, and treatment information. Goal is to determine if there are risk factors that predispose pain patients to opioid abuse.
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AoU Research Priorities Use Cases
Can we find a new class of drugs to successfully treat reflux and GERD without the potentially devastating side effects?
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AoU Research Priorities Use Cases
Does collecting side-effect data directly from patients improve compliance, personalized drug choice and efficacy?
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AoU Research Priorities Use Cases
Do tailored educational materials for patient-participants undergoing pharmacogenetic testing promote patient engagement?
To assess and compare the level of understanding, engagement and satisfaction in patients who received pharmacogenetic results and are randomized to 1) a web-based portal with personalized educational content tailored to subject's results or 2)standard of care. Subjects will be surveyed to determine 1) understanding 2) engagement and 3) satisfaction.
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AoU Research Priorities Use Cases
What are the genetic, comorbid risk factors, and anticancer agents that contribute to heart failure after cancer therapy
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AoU Research Priorities Use Cases
What medications work best for people with epilepsy?
Aim 2. Comparative Effectiveness. For each epilepsy subtype, which medication works best?
Aim 3. Pharmacogenetics. Within epilepsy subtypes, what genetic markers predict response to treatment?
(Epilepsy subtypes might include new onset focal epilepsy, new onset generalized epilepsy, Dravet syndrome, Doose... more »
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AoU Research Priorities Use Cases
Is there a correlation between readmissions and pharmacogenomic effects? Do patients who got misdosed land back in the hospital?
Medicare penalizes hospitals that must readmit patients within 30 days. To what extent are those treatment failures linked to a failure to personalize medications and dosages? Metabolism and weight changes make the elderly more sensitive to dose variation. CYP phenotyping could be requested or incentivized as part of the readmission.