AoU Research Priorities Use Cases
AoU Research Priorities Use Cases
What are the genetic, epigenetic, and environmental factors of endometriosis, and how can they help us identify its subtypes?
Endometriosis is a systemic condition with a heavy burden on patients. It is estimated that 10% of women in reproductive age have endometriosis, but its etiology is still unknown. While it is accepted that endometriosis is a heterogeneous condition, what the exact subtypes of the disease are is still an open question.
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AoU Research Priorities Use Cases
Do systemic therapies used for cure or control of diseases like cancer, HIV, or diabetes alter aging phenotypes?
Clinical evidence suggests that cancer survivors, people living with HIV/AIDS, and diabetics may age prematurely from treatment toxicity. The All of Us study could be used to study these observatons over time by comparing aging trajectories and risk factors for individuals with and without systemic therapy use and investigate the mechanisms that cause alterations in the rate or way individuals age.