Showing 2 ideas for tag "rheumatoid-arthritis"
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Can we use an mHealth app to track rheumatoid arthritis symptoms and conduct pharmacogenetics analyses for biologic drugs?

Goals: To determine genetics of response to biologic drugs in RA
Methods: Define RA with EHR algorithm, use mHealth app to record RA symptoms (RADAI), current/new meds + adherence
Outcome: daily RA disease activity after drug start
Data: EHR meds, ESR, CRP; PPI confounders, demographics, smoking, exercise.
Limitations of prior studies: small samples, no adherence or confounder info, sparse outcome data
Expected outcomes:... more »

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AoU Research Priorities Use Cases

Can we personalize prevention of rheumatoid arthritis?

Modifiable risk factors interact with genes to predict rheumatoid arthritis (RA). Antibodies can be detected in pre-RA, up to 10 years before symptoms.
Goal: Conduct RCT to reduce RA risk factors and delay/prevent RA onset
Methods.Find high risk subjects (+CCP, high polygenetic risk score), monitor for early sx (mHealth), conduct RCT based on motivational interviewing/health coaching vs. basic info intervention to modify... more »

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