Showing 6 ideas for tag "risk-factors"
Peripheral neuropathy is common in persons with diabetes and those over 40, and can be measured with validated claims data. The main disease risk factors, other than hyperglycemia, are unknown. We propose a first in kind study to simultaneously address how behavioral (diet, exercise, sleep), environmental (air quality, food access), and genetic factors influence the development of neuropathy and whether these factors... more »
Transient ischemic attack (TIA) is a frequent precursor to debilitating conditions like stroke. Existing longitudinal cohort studies of TIA have limited applicability due to the relative rarity of TIA and the changing definitions of TIA over time. All of Us provides a unique opportunity to assess the incidence of TIA under modern medical practice in this longitudinal cohort. With All of Us's extensive data collection,... more »
The ASCVD risk scores was introduced by American College of Cardiology (ACC) & American Heart Association (AHA) in 2013 to provide 10-year risk for use in Blood Cholesterol Guideline. Absence of Asian Americans in the cohorts that provided the data for developing the scores may limit its precision in these individuals. AoU offers unique opportunity to collect CVD risk factors & outcomes in Asian Americans and its heterogeneous... more »
People who smoke or have hypertension, diabetes, and hyperlipidemia are at increased risk of developing cardiovascular diseases (CVD). However, not all do, and it would be interesting to identify those with CVD risk factors but remain free of CVD. Studying these people phenotypically, genomically, environmentally, and molecularly (via -omics) could provide great insight into novel mechanisms by which new treatments... more »
Suicide is a leading cause of death and rates have not decreased in decades. Currently there are no established risk factors that have demonstrated usefulness in predicting individual risk. The All of Us program is in a position to change this by leveraging the large and varied data that will be collected. Making progress in this area would be a major advance and could have a tremendous impact on the suffering that individuals... more »
The human microbiota has been found to be associated with a number of health conditions, such as obesity. However, these studies have been relatively small and from convenience samples. It is important to understand how the human microbiota impacts these chronic disease risk factors in order to prevent future disease development. We propose collecting oral and fecal samples to determine associations with many chronic... more »