Longitudinal study with cases identified in childhood (typically, before 5-6 years of age) with the presence of febrile seizures, followed over time for the diagnosis of dementia (including mild cognitive impairment). Genetic data and viral serolgies also should be collected to identify causal/association data.
Justification: febrile seizures occur in 3-5% of the US population (i.e., most common type of seizure). Changes... more »

Initial data (e.g., demographic) and data that are noted routinely as a part of healthcare maintenance (e.g., anthropomorphic factors, blood pressure, cholesterol, serum creatinine, etc.) could be collected longitudinally and then evaluated in terms of onset of epilepsy later in life.
Justification: as the US population ages, the incidence and prevalence of epilepsy is expected to increase, given the association of epilepsy... more »