Circadian clock and/or sleep disruptions have been suggested associated with health and disease outcome. A systematic longitudinal follow up over lifespan is needed to understand the underlining mechanisms. All of Us project could provide such opportunity to evaluate the dynamic relationships of circadian clock and sleep with other multi-level factors, such as, lifestyle (diet, exercise and mental health) and behavior,... more »

Sleep participates in regulation of biological systems that support health. Sleep is experienced as restorative; and non-restorative sleep is associated with debilitating fatigue, experienced in many medical conditions. Questions are needed to assess subjective restorative quality of sleep (in the last months) together with questions about mental and physical health, sleep continuity, quality, duration and circadian timing.... more »

How can a study be accurate if the routine of the patient is changed?

REM sleep behaviour (RBD) can precede subsequent Lewy body disease by many years/decades. Thus RBD could be a potent prodromal biomarker of future disease and allow for identification of an ideal target population for disease modifying treatment. In depth assessment of sleep behaviours in midlife as measured using participant survey complimented by wearable devices technology could provide unparalleled information in... more »

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Nocturia is highly prevalent and has significant impact on quality of life. Therapeutic interventions often reduce nocturia episodes by less than one episode per night and rely on self-report data to quantify efficacy. This study will identify a cohort with nocturia and compare self-reported nocturia to actual nighttime visits to the toilet as recorded by wearable technology; and follow over time. We hypothesize that... more »

Sleep (quantity, quality, timing), sedentary behavior, and physical activity of various intensities, affect each other and many health outcomes. Health conditions affect individuals’ sleep and activity patterns. Capturing 24-hour device data repeatedly will allow exploration of multiple hypotheses about sleep, sedentary behavior, physical activity and health. Longitudinal data will allow exploration of causality in both... more »

This study will focus on the entire cohort (infant-19 y/o) to provide health and behavior outcomes associated with sleep characteristics, including environmental and demographic factors. This information will help better define the development of sleep, help develop more precise strategies to target children with sleep characteristics predictive of poor health outcomes, and develop more precise strategies for children... more »

The CDC calls insufficient sleep a "public health problem." But sleep & circadian rhythms are oft-ignored—even derided--aspects of health.

When you ask subjects about lifestyle, don't stop @ diet/exercise. Ask about sleep. When you ask about sleep, don't stop @ length/quality. Ask about circadian timing: when ppl sleep. Is timing dictated by their body clock *or* work/family demands?

AOU is an unprecedented opp to... more »

Study would seek to characterize the etiological bases, including genetic, socio-cultural and environmental, for the circadian timing, duration and quality of sleep and vulnerability to develop sleep disorders.

There is a need to include survey questions sensitive to sleep and circadian phenotypes, which may be easily administered via smart phone applications.

There is a need to understand the inter-relationships among sleep, diet, physical activity and stress on one another and health outcomes.

It would increase the utility of specimens collected in AoU if they were all time stamped, providing general circadian information.

Wearables that can capture sleep and circadian information-across the day/night and over time--should be included. Activity monitors, EEG, ECG and Oximetry measurement are increasingly accessible with miniaturization of technology. Consumer interest in many of these devices has accelerated development and driven costs down. Analysis of these data-perhaps using open-platforms- hold promise for deriving quantitative measurements... more »

Biomarkers of sleep sufficiency need to be developed for use in safety for duty and also for use as longer term health indices.