AoU Research Priorities Use Cases
AoU Research Priorities Use Cases
What are the effects of Adverse Childhood Experiences (ACEs) over the lifespan?
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AoU Research Priorities Use Cases
Understand the inter-relationships among sleep, diet, physical activity and stress on one another and health outcomes.
There is a need to understand the inter-relationships among sleep, diet, physical activity and stress on one another and health outcomes.
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AoU Research Priorities Use Cases
Does midurethral sling surgery (MuSS) for stress urinary incontinence (SUI) improve metabolic risk profile?
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AoU Research Priorities Use Cases
Preconception predictors of preterm birth
Given the limited effects of current interventions to prevent preterm birth, it seems likely that the stage for adverse pregnancy outcomes is set even before the pregnancy begins. The All of Us cohort, if sufficient reproductive-aged women are enrolled, would be in a position to examine social, behavioral, medical, and biological/molecular predictors of preterm birth and its subtypes.
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AoU Research Priorities Use Cases
How do experiences of racial discrimination relate to HPA axis activity and the prevalence of chronic illnesses?
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AoU Research Priorities Use Cases
Can improvement in emotional health using psychotherapy increase physical health while reducing risk factors of obesity.
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AoU Research Priorities Use Cases
To develop or optimize a non-invasive TECHNOLOGY that can be used to measure the experience of stress in children and adults.
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AoU Research Priorities Use Cases
To develop or optimize a non-invasive BIOMARKER that can be used to measure the experience of stress in children and adults.
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AoU Research Priorities Use Cases
Does psychosocial stress influence time to cancer recurrence or cancer survival for various tumor types?
In animal models, stress is a trigger for tumor growth and metastasis, yet we have not adequately addressed this question in human cancer patients or survivors.
All of Us could longitudinally assess the biological experience of psychosocial stress (via biomarker or wearable technology) at specified times in the cancer survivorship period, and conduct an analysis of time to recurrence or time to death.
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AoU Research Priorities Use Cases
Do stress-reducing activities or interventions influence time to cancer recurrence or cancer survival?
Randomized trials could be set within All of Us to test these interventions at specific research sites.
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AoU Research Priorities Use Cases
How does chronic stress influence the persistence of oncogenic viruses or bacteria in otherwise healthy adults?
Chronic stress has significant suppressive impact on the immune system and would influence the risk of infection-associated cancers if high risk infections are allowed to persist. In general populations and healthy adult populations, this question has not been addressed. It would involve serial measurement of oral or anogenital human papillomavirus, or even helicobacter pylori.
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AoU Research Priorities Use Cases
Would the addition of non-selective beta-blockers to cancer therapy result in better survival?
Animal models are compelling that activating the beta-adrenergic pathway (via stress) results in tumor growth and metastasis. Beta-blockers blunt this effect in animals. All of Us could design a randomized intervention trial to test this potential benefit in humans. An observational approach could also be taken with careful attention to pharmacoepi principles and biases such as confounding by indication.
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AoU Research Priorities Use Cases
AoU’s sample/measures uniquely allow for modeling high-burden disease pathways specified by the biopsychosocial ecological model
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AoU Research Priorities Use Cases