This study will focus on the entire cohort (infant-19 y/o) to provide health and behavior outcomes associated with sleep characteristics, including environmental and demographic factors. This information will help better define the development of sleep, help develop more precise strategies to target children with sleep characteristics predictive of poor health outcomes, and develop more precise strategies for children... more »

Much of what we know about ACEs is retrospective yet we believe that there are developmental touch points and/or aspects of resilience that help or hinder the biologic stress that may or may not ensue after an adverse experience. Monitoring parent and child adversity and stress over time will clarify a much needed field where we know that ACEs cause acceleration of physical, mental and behavioral health problems in... more »

There is a need to understand the inter-relationships among sleep, diet, physical activity and stress on one another and health outcomes.

SUI may contribute to reduced physical activity and poorer adherence to diuretics, thereby increasing metabolic risk profile. This study will identify a prospective subcohort of women aged 18+ with incident MuSS to compare metabolic risk profile before and after successful surgery. We hypothesize successful MuSS will decrease need to urinate during day, increase level of physical activity, and reduce metabolic risk. Patient... more »

Given the limited effects of current interventions to prevent preterm birth, it seems likely that the stage for adverse pregnancy outcomes is set even before the pregnancy begins. The All of Us cohort, if sufficient reproductive-aged women are enrolled, would be in a position to examine social, behavioral, medical, and biological/molecular predictors of preterm birth and its subtypes.

Instances of racial discrimination activate the HPA axis, and this chronic activation may be related to the disproportionate prevalence of chronic illnesses in members of racial minority groups. Some studies have found a blunted cortisol concentration in African Americans, compared to Caucasians. However, it's unknown whether all members of racial minority groups have a blunted cortisol concentration, and how it relates... more »

Black Therapists Rock engages over 19,000 psychotherapists who work with vulnerable populations. We have noticed a correlation of improved health outcomes in clients who have utilized Internal Family Systems (IFS), a psychotherapy model that focuses on healing the emotional wounds developed in childhood. We wish to expand upon this data, by employing more therapists to use this model, while advocating/recruiting participants... more »

The impact of psychosocial stress on child and adult health risk is increasingly appreciated. The measurement of this exposure is currently poor, and All of Us has the opportunity to develop or refine wearable technologies that could help push this field of research forward in a valid way for the future. Such technology could be a part of individual studies of stress and disease, and could also be used as a gold standard... more »

The impact of psychosocial stress on child and adult health risk is increasingly appreciated. The measurement of this exposure is currently poor, and All of Us has the opportunity to develop or refine biomarkers that could help push this field of research forward in a valid way for the future. Such biomarkers could be a part of individual studies of stress and disease, and could also be used as a gold standard to develop... more »

In animal models, stress is a trigger for tumor growth and metastasis, yet we have not adequately addressed this question in human cancer patients or survivors.

All of Us could longitudinally assess the biological experience of psychosocial stress (via biomarker or wearable technology) at specified times in the cancer survivorship period, and conduct an analysis of time to recurrence or time to death.

Randomized trials could be set within All of Us to test these interventions at specific research sites.

Chronic stress has significant suppressive impact on the immune system and would influence the risk of infection-associated cancers if high risk infections are allowed to persist. In general populations and healthy adult populations, this question has not been addressed. It would involve serial measurement of oral or anogenital human papillomavirus, or even helicobacter pylori.

Animal models are compelling that activating the beta-adrenergic pathway (via stress) results in tumor growth and metastasis. Beta-blockers blunt this effect in animals. All of Us could design a randomized intervention trial to test this potential benefit in humans. An observational approach could also be taken with careful attention to pharmacoepi principles and biases such as confounding by indication.

Biological, psychological & social domains interact at multiple levels (genes, human & environment microbiomes, stress, behavior, broad SES & environment) outlined by the biopsychosocial ecological model (BPSEM). The BPSEM specifies pathways aligned with the AoU pillars of biology, lifestyle, & environment. Simultaneous examination of the interacting domains and levels of the BPSEM is now computationally possible and... more »

Research has shown that benefits of health behaviors such as diet, exercise, and stress depend not just on the behaviors themselves but on the mindsets people have about those behaviors (Crum, Achor & Salovey, 2013; Zahrt & Crum 2017; Turnwald, Boles & Crum 2017); however, large-scale databases have not yet included measures of mindset. The goal of this study is to use validated measures of exercise, stress and diet mindsets... more »