Showing 12 ideas for tag "stroke"
(@renaissance) kudos icon +

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How reliably do epigenetic aging clocks predict disease onset and mortality? Can they be slowed or reversed?

An annual blood test with analysis of methylation sites from key epigenetic aging clocks (e.g. Horvath). Epigenetic aging clocks have already been shown to reliably predict age, time-to-death, all cause mortality, cog. function, immune function, CV disease, cancer, and more. They may also become a key tool to demonstrate the reversibility of disease risk through dietary and therapeutic regimens, as epigenetic states are... more »

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35 votes
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(@rkchang) kudos icon +

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Electrocardiogram (ECG) and genomics in predicting coronary heart disease, MI, arrhythmia, stroke and sudden cardiac death

Electrocardiogram (ECG) is the most commonly used test to check on heart health and screen for heart disease. Medical standard 12-lead ECG holds a lot of information about the heart, which together with genomic data have the potential to predict which patients will develop coronary heart disease, myocardial infarction (MI), arrhythmia, stroke and sudden cardiac death. With 1 million people's ECG and genomic data, together... more »

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17 votes
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(@lyn.jakeman) kudos icon +

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What are the risk factors for comorbid health outcomes in persons with immobility caused by neurological injury or disease?

This would focus on incidence of health problems in the entire cohort to ask if loss of mobility or neurological impairment are separate risk factors. Demographic and pre-enrollment ICD codes will be obtained with the All of Us Core dataset. Volunteers will be followed for 5 years with annual PPI, physical exams, and blood draws. ICD codes will be obtained at any clinical encounters. Principle component analysis will... more »

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7 votes
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(@adam.hartman) kudos icon +

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What are the risk factors (genetic, environmental, other biological) for developing epilepsy later in life?

Initial data (e.g., demographic) and data that are noted routinely as a part of healthcare maintenance (e.g., anthropomorphic factors, blood pressure, cholesterol, serum creatinine, etc.) could be collected longitudinally and then evaluated in terms of onset of epilepsy later in life.
Justification: as the US population ages, the incidence and prevalence of epilepsy is expected to increase, given the association of epilepsy... more »

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12 votes
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(@clinton.wright) kudos icon +

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What hypertension medicine regimen is most effective to prevent complications (kidney, heart, and brain) over the lifecourse?

Blood pressure and anti-hypertensive medication use will be collected at baseline through physical examination and medical history taking as well as from the EHR. Track blood pressure and changes in medication to examine different regimens and degrees of blood pressure control as predictors of vascular complications, while using continuing medical care to understand the role of potential co-morbidities and medication... more »

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8 votes
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(@ginawei) kudos icon +

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Toward a more precise risk prediction for ischemic stroke in Asians Americans with Atrial Fibrillation (AF)

Research in Asia vs. findings in U.S. suggest risk of ischemic stroke AND bleeding with oral anticoagulant may be higher in East Asian vs. non-Asian AF patients. However, data is lacking in Asians living in the U.S. With its diversity goal, AoU is expected to recruit substantive number of Asian Americans. AoU can be leveraged to see whether this finding extends to Asian Americans, who have different exposures (behavioral,... more »

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6 votes
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(@dmarriot) kudos icon +

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Treatments to reduce risk of stroke following a transient ischemic attack (TIA)

Transient ischemic attack (TIA) is a frequent precursor to stroke. Studies of modern treatments (e.g., carotid endarterectomy and carotid artery stenting) do not consider TIA as an indicator for treatment, nor which treatments may be more effective following a TIA. All of Us provides a unique opportunity to not only examine the interaction between TIA and treatment to prevent subsequent strokes, but also to suggest... more »

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4 votes
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(@lisa.signorello) kudos icon +

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To what extent are adverse childhood experiences (ACE) or trauma related to a wide range of adult diseases or premature death?

Adverse childhood experiences (ACE) can be retrospectively assessed in adults, ideally before the onset of the diseases under study. There are existing ACE instruments, or attempts to refine these instruments could be undertaken within All of Us.

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5 votes
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(@mkballasiotes) kudos icon +

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What are the best practices to optimize motor rehabilitation in children with stroke? (Can also include cerebral palsy.)

Key Problem: Over 60% of children with strokes have permanent neurological deficits, most common being hemiplegia. The impact of stroke on motor skills vary, therefore it will not be responsive to one single curative treatment. Pediatric stroke requires a multi-disciplinary approach to rehabilitation for optimal outcome. No standard of care exists for these children.
Proposed Study: Asses & survey what multidisciplinary... more »

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1 vote
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(@mkballasiotes) kudos icon +

AoU Research Priorities Use Cases

What are the best acute management strategies for children with stroke?

Key problem: While there is research and advances on treatment for adult stroke, acute stroke treatment for pediatrics has not been included. The TIPS trial (tPA in peds) was terminated due to lack of enrollment. Hence, there are no guidelines for treating acute stroke in children. Lack of timely medical intervention can result in more profound disabilities or death.
Methods: Conduct research to identify safe and effective... more »

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1 vote
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