Showing 7 ideas for tag "treatment"
(@sjogrens.syndrome.foundation) kudos icon +

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Can we find better treatments for neuropathic numbness and pain in Sjögren's and other autoimmune diseases?

Peripheral neuropathies are common in Sjögren's and related autoimmune diseases and can be a presenting symptom of Sjögren's. Burning pain and numbness in the extremities, trigeminal neuralgias, weakness, poor balance and altered gait can occur. Symptoms can interfere greatly with quality of life and function. This study would focus on identifying better treatments to address these symptoms in Sjögren's and autoimmune... more »

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26 votes
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(@sjogrens.syndrome.foundation) kudos icon +

AoU Research Priorities Use Cases

Can we improve the identification and management of Sjögren's in children?

Children often present differently with Sjögren's when compared with adults leading to delayed diagnosis and treatment. Additionally, awareness of Sjögren's in children among clinicians is low, which may further delay diagnosis and treatment. This study would focus on learning how to better identify, manage, and treat Sjögren's in this special population and how disease expression and pathways differ in children compared... more »

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20 votes
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(@rapopd) kudos icon +

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Looking at consequences of obstructive sleep apnea in terms of overall treatment (across all modes of treatment)

Studies of OSA have so far focused on whether any one treatment (CPAP, dental appliances. hypoglossal stimulation, surgery, etc) has an impact on outcomes.Physiologically all that matters is whether the OSA is improved. Studies can be designed using as a metric whether any treatment (or combination) reduces the AHI or any other metric of severity of the OSA. This pooled data can then be related to any desired outcome... more »

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17 votes
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(@laura.kwako) kudos icon +

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Why do so few people seek specific treatment for alcohol use disorder?

Alcohol use disorder (AUD) is a common problem with a significant public health impact. Despite available treatments of various types, fewer than 10% of individuals diagnosed with an AUD receive specific treatment for this disease. Identifying the factors that prevent individuals from seeking treatment could better improve access to treatment, thereby eliminating disease burden.

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8 votes
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(@dmarriot) kudos icon +

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Treatments to reduce risk of stroke following a transient ischemic attack (TIA)

Transient ischemic attack (TIA) is a frequent precursor to stroke. Studies of modern treatments (e.g., carotid endarterectomy and carotid artery stenting) do not consider TIA as an indicator for treatment, nor which treatments may be more effective following a TIA. All of Us provides a unique opportunity to not only examine the interaction between TIA and treatment to prevent subsequent strokes, but also to suggest... more »

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4 votes
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(@hhenrylai) kudos icon +

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What are the biological and behavioral factors that predict mesh complications after sling for stress urinary incontinence?

Stress urinary incontinence (SUI) is prevalent among women, yet the standard of care treatment – midurethral mesh sling – can lead in devastating mesh complications (dyspareunia that precludes sex, chronic pelvic pain, infection). Using national data, we will identify biological (eg, genomics, vaginal & urinary microbiome, race, comorbidities, metabolic syndrome) and behavioral (eg, smoking, physical activity) factors... more »

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2 votes
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(@mkballasiotes) kudos icon +

AoU Research Priorities Use Cases

What are the best acute management strategies for children with stroke?

Key problem: While there is research and advances on treatment for adult stroke, acute stroke treatment for pediatrics has not been included. The TIPS trial (tPA in peds) was terminated due to lack of enrollment. Hence, there are no guidelines for treating acute stroke in children. Lack of timely medical intervention can result in more profound disabilities or death.
Methods: Conduct research to identify safe and effective... more »

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1 vote
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