Submitted by: NEI Collaborative Clinical Research Program Officers
Diabetes often leads to end-organ complications, one of which is diabetic retinopathy and vision loss. This has a significant impact on quality of life for the diabetic patient. Finding genetic determinants would be predictive for this outcome within the diabetic population and may potentially lead to therapeutic interventions.
In October 2017, Jiang Zhang and Toshihiko Matuso have published "MGSTX and WNT2 are candidate genes for comitant strabismus susceptibility in Japanese patients" (PeerJ 5:33935). I suggest replicating this study in other national groups. Then, knock-out the identified genes in animal models before proceeding to human therapy.