An annual blood test with analysis of methylation sites from key epigenetic aging clocks (e.g. Horvath). Epigenetic aging clocks have already been shown to reliably predict age, time-to-death, all cause mortality, cog. function, immune function, CV disease, cancer, and more. They may also become a key tool to demonstrate the reversibility of disease risk through dietary and therapeutic regimens, as epigenetic states are... more »

This study will focus on the entire cohort (menarche through lifespan) to collect data on general health and wellbeing as well as detailed pregnancy & delivery histories. Activity level will be monitored, specifying any straining associated with either physical activity or occupation. Genetic/epigenetic factors, such as family history of POP or connective tissue disorders will be obtained, as will data on other currently... more »

Neurons are mostly non-renewing cells and neurodegenerative diseases are often diagnosed after many already died. This severely limits therapeutic efficacy. We propose accurate, convenient measures of broad neurological functions using developed smartphone apps to test whether derived subject-specific progression slopes can differentiate healthy aging from incipient neurological dysfunction. Such analysis may eventually... more »

The microbiome variations have been associated with health and disease status in cross-sectional studies. There is a need to examine these associations in a longitudinal fashion and to establish baseline changes in health and disease over a lifespan. All of Us Together provides a game-changing amount of longitudinal data on enough individuals to begin to map the complex relationship between exposures (diet, antibiotics,... more »

The NIDCD estimates that age related hearing loss, or presbycusis, affects 1 in 3 individuals in the United States between 65 and 74 years old, and nearly half of those older than 75. Despite this large burden, few genetic risk factors have been identified, and it is unclear how genetics and environment interact to influence hearing loss susceptibility. I propose to measure hearing loss progression in the All of Us cohort,... more »

Identify the population of individuals who are age 100 years half who may have had a cancer diagnosis and half with no cancer diagnosis in their lifetime.
Survey those individuals as to their life experiences - medical history, employment history, lifestyle, exercise history, diet etc
Individuals will provide a blood sample for complete genetic analysis.
What genetic mutations are present which may cause cancer yet... more »

From NEI Working Group on AMD
Use cohort with structural and functional phenotyping with genetic and EHRs to identify risk factors, and their interactive effects, for AMD development/progression. A subset could be identified based on AMD or family history of AMD (via EHRs), or presence of high-risk variants (via WGS), and could then be followed annually with fundus autofluorescence, OCT, dark adaptation. Additional... more »

Medicare penalizes hospitals that must readmit patients within 30 days. To what extent are those treatment failures linked to a failure to personalize medications and dosages? Metabolism and weight changes make the elderly more sensitive to dose variation. CYP phenotyping could be requested or incentivized as part of the readmission.

Clinical evidence suggests that cancer survivors, people living with HIV/AIDS, and diabetics may age prematurely from treatment toxicity. The All of Us study could be used to study these observatons over time by comparing aging trajectories and risk factors for individuals with and without systemic therapy use and investigate the mechanisms that cause alterations in the rate or way individuals age.