AoU Research Priorities Use Cases
AoU Research Priorities Use Cases
What genetic and environmental risk factors contribute to the development of pelvic organ prolapse (POP) as females age?
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AoU Research Priorities Use Cases
Differentiating healthy neurological aging from incipient nervous system dysfunction using smartphone apps.
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AoU Research Priorities Use Cases
Evaluate Age-related Microbiota Changes and their impact in Health, and in Chronic Disease Prevention, Treatment and Progression
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AoU Research Priorities Use Cases
What genetic and environmental factors influence the progression of hearing loss in aging adults (presbycusis)?
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AoU Research Priorities Use Cases
Use genetic sequencing to Identify what factors account for some individuals to live to 100 years without developing canc
Survey those individuals as to their life experiences - medical history, employment history, lifestyle, exercise history, diet etc
Individuals will provide a blood sample for complete genetic analysis.
What genetic mutations are present which may cause cancer yet... more »
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AoU Research Priorities Use Cases
Can we identify risk factors for Age Related Macular Degeneration (AMD) ?
Use cohort with structural and functional phenotyping with genetic and EHRs to identify risk factors, and their interactive effects, for AMD development/progression. A subset could be identified based on AMD or family history of AMD (via EHRs), or presence of high-risk variants (via WGS), and could then be followed annually with fundus autofluorescence, OCT, dark adaptation. Additional... more »
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AoU Research Priorities Use Cases
Is there a correlation between readmissions and pharmacogenomic effects? Do patients who got misdosed land back in the hospital?
Medicare penalizes hospitals that must readmit patients within 30 days. To what extent are those treatment failures linked to a failure to personalize medications and dosages? Metabolism and weight changes make the elderly more sensitive to dose variation. CYP phenotyping could be requested or incentivized as part of the readmission.
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AoU Research Priorities Use Cases
Do systemic therapies used for cure or control of diseases like cancer, HIV, or diabetes alter aging phenotypes?
Clinical evidence suggests that cancer survivors, people living with HIV/AIDS, and diabetics may age prematurely from treatment toxicity. The All of Us study could be used to study these observatons over time by comparing aging trajectories and risk factors for individuals with and without systemic therapy use and investigate the mechanisms that cause alterations in the rate or way individuals age.