AoU Research Priorities Use Cases
AoU Research Priorities Use Cases
Criteria for Environmental Associated Autoimmune Diseases
Goal: Survey patients with autoimmune diseases for information on occupational and other life style exposures to factors associated with autoimmunity (smoking, silica dust, solvents, etc). Build data bases containing clinical parameters, blood tests, and exposure data to help identify putative diagnostic criteria. Compare with patients having idiopathic autoimmunity (i.e. lacking known risk exposures)
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AoU Research Priorities Use Cases
Can allergies predict the development of autoimmune or inflammatory disease? Does treatment reduce the risk?
Identify a group of participants with environmental/food allergies and ask if the allergies are well controlled. Use observational data over many years to determine the relative rate of development of autoimmune/inflammatory illness in participants whose allergies are/are not well controlled.
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AoU Research Priorities Use Cases
Can we develop better diagnostic testing for autoimmune diseases?
The process of diagnosis for autoimmune disease is often prolonged and difficult. Current testing (e.g. ANA test) is often not well-correlated with the disease status and can impede diagnosis. A longitudinal study could be done with this data set to look for other biomarkers that might be better correlated with disease state, facilitating early diagnosis.
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AoU Research Priorities Use Cases
What are the common threads between autoimmune diseases and what do people with autoimmune diseases have in common?
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AoU Research Priorities Use Cases
How are autoimmune diseases related to cancers, and can we share new knowledge across these two fields?
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AoU Research Priorities Use Cases
What specific factors contribute to the reoccurrence of latent/dormant human viruses such as herpes simplex, Epstein-Barr, parvo
Comparisons of patients with autoimmune diseases and latent viruses with a control groups having only one factor ensuring a statistically representative sample by gender, age, and race.
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AoU Research Priorities Use Cases
Does exposure to environmental chemicals, such as PFAS, affect incidence of autoimmune disease in young adults?
By prospectively assessing exposures to environmental chemicals, such as per- and polyfluoroalkyl substances (PFAS), All of Us could evaluate whether these exposures are contributing to the rising incidence of autoimmune diseases in young adults. Intermediate biological outcomes related to thyroid function, inflammation, and immune response could be assessed.
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AoU Research Priorities Use Cases
Why do individuals with autoimmune diseases have an increased risk of lymphoma and how can we prevent it?
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AoU Research Priorities Use Cases
What are the long term effects of biopharmaceuticals (biologics) on children exposed in utero?
Tens of millions of Americans are effected by autoimmune diseases, a majority of which are women. Biopharmaceuticals are prescribed even during pregnancy. It is assumed maternal health is monitored closely as it fetal health, however, what are the long term effects on the child's health and how do biopharmaceuticals effect those children's long term disease risk profiles.
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AoU Research Priorities Use Cases
How do inflammation and subclinical autoimmunity impact adverse reproductive health?
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AoU Research Priorities Use Cases