I proposed that the 1950s-60s CHD deaths were associated with H1-H2 Influenza A re-infectiosn of H3 Influenza primed individuals (born around 1890). After 1968, when the H3 influenza virus returned, high serum cholesterol CHD cases declined and a second atherogenic phenotype emerged (H3 re-infection of H1-primed cohorts born after 1900 and more after 1918?). Would CHD mortality with high serum cholesterol levels increase... more »

Biological, psychological & social domains interact at multiple levels (genes, human & environment microbiomes, stress, behavior, broad SES & environment) outlined by the biopsychosocial ecological model (BPSEM). The BPSEM specifies pathways aligned with the AoU pillars of biology, lifestyle, & environment. Simultaneous examination of the interacting domains and levels of the BPSEM is now computationally possible and... more »