Showing 27 ideas for tag "diet"
(@subara) kudos icon +

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What are the associations between diet and health outcomes?

Dietary intake is a complex and dynamic exposure known to affect health. To best assess foods, nutrients, dietary supplements and dietary patterns and any latency in their relationship to disease, longitudinal collection every year of both long- and short-term dietary assessment instruments is necessary. To fully adjust for systematic error, replicated recovery and predictive biomarkers should be collected in a 10-20%... more »

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18 votes
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(@mpwhitmire) kudos icon +

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What is the malnutrition risk of older adults living in the community?

It is important that the All of Us database includes a range of nutrition-related measures--not just diet and BMI--but other parameters such as weight history and appetite history which are used to help identify malnutrition risk. Additional measures of malnutrition-related characteristics are important for malnutrition diagnosis. Validated screening tools such as the Malnutrition Screening Tool (MST) could be used regularly... more »

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13 votes
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(@floresr2) kudos icon +

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Dietary and microbial-derived metabolites may modulate body weight and contribute to overweight and obesity.

Integrate multi-omic approaches (metabolomic, proteomic, inflammasome, microbiome analyses) with dietary assessment and clinical data in a nested cohort study. Dietary and/or microbial metabolites may modulate body weight and may influence other comorbidities. A comprehensive analysis of inflammatory and metabolic biomarkers of oxidative stress, nutritional assessment, short chain fatty acids and other microbial metabolites... more »

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14 votes
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(@zoradjuric) kudos icon +

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Does weight gain negate the beneficial effects of eating healthy foods?

Adult weight gain and obesity increase risks of chronic diseases. The effects of a positive energy balance could outweigh any beneficial effects of foods associated with reduced health risks such as vegetables, whole grains and omega-3 fatty acids. In subsets of adults who are either gaining weight or maintaining weight over time, does the impact of diet quality on health risks differ? Diet could be quantified by various... more »

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10 votes
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(@ataylor) kudos icon +

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What midlife lifestyle factors make someone more or less likely to develop dementia with Lewy bodies?

Exercise, socialization, cognitive training, education, dietary habits and environmental exposures interacting with genetic profiles are suggested to raise the risk of Alzheimer’s dementia. Less is known about environmental, genetic and epigenetic contributors to raising the risk of dementia with Lewy bodies. Large scale data sets would allow first-of-its-kind enhanced profiling in multi-path analyses key midlife factors... more »

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8 votes
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(@svogelstein) kudos icon +

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What is the long-term impact of consumption of organic foods on health outcomes?

Organic foods are thought to be healthier than conventional foods because of the limited exposure to pesticides and other chemicals. Few studies have examined the long-term health effects of organic foods. By collecting information on organic food consumption and comparing those who tend to consume more organic foods (e.g., organic fruits/veg) to those who consume less, we could evaluate the impact of organic food consumption... more »

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11 votes
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(@tyrolk) kudos icon +

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How Well Do Recipients of Weight-Loss Surgery (WLS) Believe They Were Informed of the Risks and Restrictions The Surgery Poses

WLS poses a variety of risks as well as a very specific set of restrictions: initially a highly restricted diet that relaxes over time. These risks/restrictions carry with them an emotional & sociocultural cost that is difficult to convey. I propose juxtaposing provider expectations of patient knowledge about risks and restrictions w/ patient reflections on the nuanced meaning of same. What do patients wish they'd known... more »

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4 votes
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(@svogelstein) kudos icon +

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What etiology factors contribute to the onset of seizures in late adulthood?

The incidence of seizures increases after the age of 50 years. With the increased life expectancy, seizures in older adults represents an emerging and important public health concern. Although cerebrovascular disease contributes to some cases, the etiology of these seizures in most patients is large known. Metabolic factors are likely to contribute to risk in some patients as diet changes can reduce the frequency of seizures... more »

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3 votes
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AoU’s sample/measures uniquely allow for modeling high-burden disease pathways specified by the biopsychosocial ecological model

Biological, psychological & social domains interact at multiple levels (genes, human & environment microbiomes, stress, behavior, broad SES & environment) outlined by the biopsychosocial ecological model (BPSEM). The BPSEM specifies pathways aligned with the AoU pillars of biology, lifestyle, & environment. Simultaneous examination of the interacting domains and levels of the BPSEM is now computationally possible and... more »

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1 vote
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(@mbl2018) kudos icon +

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How do our mindsets about diet, exercise, and stress influence health behaviors and health outcomes?

Research has shown that benefits of health behaviors such as diet, exercise, and stress depend not just on the behaviors themselves but on the mindsets people have about those behaviors (Crum, Achor & Salovey, 2013; Zahrt & Crum 2017; Turnwald, Boles & Crum 2017); however, large-scale databases have not yet included measures of mindset. The goal of this study is to use validated measures of exercise, stress and diet mindsets... more »

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