AoU Research Priorities Use Cases
AoU Research Priorities Use Cases
Is there an association between chemical exposures and neurological disease?
Epidemiological studies and anecdotal reports suggest an association between certain neurological diseases (e.g. Parkinson's, Alzheimer's, ALS, various neurodevelopmental disorders) and chemical exposures (pesticides,metals, endocrine disruptors) via residential, occupational, and other activities. The study, using genetic information captured could also possible shed light on Gene-Environment interactions as well.
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AoU Research Priorities Use Cases
Role of Persistent Co-infections in Health and Disease
Co-infections can significantly alter disease risk, incidence, prevalence, aggressiveness, treatment response and outcomes, in addition to, making it more difficult to manage and treat the diseases. Compare differences in host response to co-infections, disease risk and treatment response to elucidate how the ubiquitous co-infections contribute to variations in disease incidence and outcomes.
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AoU Research Priorities Use Cases
What are the common threads between autoimmune diseases and what do people with autoimmune diseases have in common?
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AoU Research Priorities Use Cases
What are the risk factors for comorbid health outcomes in persons with immobility caused by neurological injury or disease?
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AoU Research Priorities Use Cases
What characteristics are associated with maintenance of increased water intake in persons with urinary stone disease?
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AoU Research Priorities Use Cases
What are key communication gaps in chronic kidney disease care between physicians and patients who belong to underserved groups?
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AoU Research Priorities Use Cases
What characteristics are associated with urinary stone recurrence in persons with prior episode of urinary stone disease?
Urinary stone disease is burdensome and costly, and frequently recurs. Via the EHR and qualitative/quantitative methods, we will identify person and intervention characteristics associated with urinary stone recurrence. Factors associated with recurrence may provide potential treatment targets for preventing stone recurrence.
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AoU Research Priorities Use Cases
Can inclusion of erectile dysfunction (ED) improve prediction of incident cardiovascular disease (CVD)?
Recent epidemiological evidence shows ED is associated with CVD, suggesting ED may be a prodrome of CVD. We proposed to assess associations between ED preceding CVD to confirm this association in the large and diverse All of Us cohort. Additionally, ED will be added to the existing Framingham risk prediction equation to determine if inclusion of ED improves the model.
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AoU Research Priorities Use Cases
Why assess diet and dietary supplements in the population?
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AoU Research Priorities Use Cases
Can the recycling of influenza viruses explain changes in phenotypes of CHD cases?
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AoU Research Priorities Use Cases
To what extent are adverse childhood experiences (ACE) or trauma related to a wide range of adult diseases or premature death?
Adverse childhood experiences (ACE) can be retrospectively assessed in adults, ideally before the onset of the diseases under study. There are existing ACE instruments, or attempts to refine these instruments could be undertaken within All of Us.
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AoU Research Priorities Use Cases
To develop or optimize a non-invasive BIOMARKER that can be used to measure the experience of stress in children and adults.
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AoU Research Priorities Use Cases
What disease risk variants are unique to naturalized citizens of recent African origin and enriched in African-Americans?
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AoU Research Priorities Use Cases
In DISH calcifications, what causes ligaments to ossify and how can we further expand treatment given that information?
Research needs to be done to develop improved treatment options, and perhaps animal models can be used to understand mechanisms and to test new medicines. Outcomes from such research can lead to new therapies and methods to reverse the condition and the at least, halt the progression of... more »