Economic and sociological drivers impact access to individualized specialty health care. This study would examine the role of age (pediatric, geriatric), gender, or ethnicity specialty expertise on patient outcomes. Demographic information would be combined with survey information about access to specialty medical care expertise. Outcomes would be determined by PPI and EHR, to include admissions, length of stay, disability... more »

Epidemiological studies and anecdotal reports suggest an association between certain neurological diseases (e.g. Parkinson's, Alzheimer's, ALS, various neurodevelopmental disorders) and chemical exposures (pesticides,metals, endocrine disruptors) via residential, occupational, and other activities. The study, using genetic information captured could also possible shed light on Gene-Environment interactions as well.

Co-infections can significantly alter disease risk, incidence, prevalence, aggressiveness, treatment response and outcomes, in addition to, making it more difficult to manage and treat the diseases. Compare differences in host response to co-infections, disease risk and treatment response to elucidate how the ubiquitous co-infections contribute to variations in disease incidence and outcomes.

Goal - Survey patients with Celiac Disease, Hashimotos and other autoimmune diseases to evaluate lifestyle, environment, food, antibiotics, and previous stomach viruses to see what has triggered the onset of various autoimmune diseases. Is the similarity of the molecules that the body attacks significant (ex- thyroid and gluten)? If left unaddressed more autoimmune diseases can develop. What do people with autoimmune... more »

This would focus on incidence of health problems in the entire cohort to ask if loss of mobility or neurological impairment are separate risk factors. Demographic and pre-enrollment ICD codes will be obtained with the All of Us Core dataset. Volunteers will be followed for 5 years with annual PPI, physical exams, and blood draws. ICD codes will be obtained at any clinical encounters. Principle component analysis will... more »

Increased water intake reduces stone recurrence, but maintaining increased intake is challenging. Via the EHR and qualitative/quantitative methods, we will identify person and intervention characteristics associated with maintenance of increased intake to determine factors that facilitate intervention success and/or enable targeted interventions. Findings may provide insights into strategies for maintenance of behavior... more »

This would be a mixed methods study. The qualitative section would involve interviews to ascertain gaps in in chronic kidney disease communication (likely risk assessment in CKD progression, information about dialysis options, mental health, advance care planning). This would be followed by surveys of patient-reported measures of communication, such as CAT (Communication Assessment Tool; https://www.ncbi.nlm.nih.gov/pubmed/17574367).... more »

Urinary stone disease is burdensome and costly, and frequently recurs. Via the EHR and qualitative/quantitative methods, we will identify person and intervention characteristics associated with urinary stone recurrence. Factors associated with recurrence may provide potential treatment targets for preventing stone recurrence.

Recent epidemiological evidence shows ED is associated with CVD, suggesting ED may be a prodrome of CVD. We proposed to assess associations between ED preceding CVD to confirm this association in the large and diverse All of Us cohort. Additionally, ED will be added to the existing Framingham risk prediction equation to determine if inclusion of ED improves the model.

Over half of US adults and one-third of children take at least one dietary supplement. Combined with intakes of foods, total nutrient intake can be estimated and linked to health outcomes in etiologic research. Such population data can inform guidance, such as the Dietary Guidelines for Americans and Dietary Reference Intakes. Supplements may be warranted for sub-groups where nutritional requirements may not be met through... more »

I proposed that the 1950s-60s CHD deaths were associated with H1-H2 Influenza A re-infectiosn of H3 Influenza primed individuals (born around 1890). After 1968, when the H3 influenza virus returned, high serum cholesterol CHD cases declined and a second atherogenic phenotype emerged (H3 re-infection of H1-primed cohorts born after 1900 and more after 1918?). Would CHD mortality with high serum cholesterol levels increase... more »

Adverse childhood experiences (ACE) can be retrospectively assessed in adults, ideally before the onset of the diseases under study. There are existing ACE instruments, or attempts to refine these instruments could be undertaken within All of Us.

The impact of psychosocial stress on child and adult health risk is increasingly appreciated. The measurement of this exposure is currently poor, and All of Us has the opportunity to develop or refine biomarkers that could help push this field of research forward in a valid way for the future. Such biomarkers could be a part of individual studies of stress and disease, and could also be used as a gold standard to develop... more »

To better understand variants relevant to African-Americans and their disease risk it would be helpful to have data on reference African populations from the African ethnic groups with the greatest historical genetic contribution through the transatlantic slave trade. Naturalized U.S. citizens born in Africa would be more easily accessible to regional sequencing leaders (e.g. Houston has the largest Nigerian U.S. population... more »

Findings answers may not only open doors to relieving the pain and misery of this disease but also for many other related diseases.

Research needs to be done to develop improved treatment options, and perhaps animal models can be used to understand mechanisms and to test new medicines. Outcomes from such research can lead to new therapies and methods to reverse the condition and the at least, halt the progression of... more »