The exposome has been defined as the totality of environmental exposures throughout the life-course. Regardless of the definition it is as a tool for the untargeted hypothesis free discovery of associations between environmental exposures and disease outcomes. This is best applied to high prevalence phenotypes that are likely to occur in the cohort such as the conversion of metabolic syndrome to overt diabetes where it... more »

Using biospecimens of persons of varying ages, characterize exposure to environmental chemicals and metals over time and conduct omics studies to identify the functional mechanism of observed health effects - gene expression, metabolomics, epigenetics and genetic variants. Most important, have a plan for integrating the findings of these various studies.

The human epigenome is altered by environmental pollutants, including particulate air pollution, bisphenol A, phthalates, metals, pesticides, dioxin-like compounds, and persistent organic pollutants. All of us will be uniquely positioned to link exposure to environmental chemicals with alterations in the human epigenome. This will require refined measures of environmental exposure that—if measured in All of us—will cause... more »

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