AoU Research Priorities Use Cases
AoU Research Priorities Use Cases
How reliably do epigenetic aging clocks predict disease onset and mortality? Can they be slowed or reversed?
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AoU Research Priorities Use Cases
What genetic markers predict consequences of pregnancy associated hypertension & gestational diabetes for mothers & offspring?
This study will focus on women who are pregnant at enrollment or become pregnant during the study and the offspring of observed pregnancies. The information will help to define genetic and epigenetic predictors of long-term effects of common pregnancy complications.
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AoU Research Priorities Use Cases
What factors are involved in loss of fecundity in males and females?
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AoU Research Priorities Use Cases
What genetic and environmental risk factors contribute to the development of pelvic organ prolapse (POP) as females age?
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AoU Research Priorities Use Cases
Preconception predictors of preterm birth
Given the limited effects of current interventions to prevent preterm birth, it seems likely that the stage for adverse pregnancy outcomes is set even before the pregnancy begins. The All of Us cohort, if sufficient reproductive-aged women are enrolled, would be in a position to examine social, behavioral, medical, and biological/molecular predictors of preterm birth and its subtypes.
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AoU Research Priorities Use Cases
Is there a genetic component to conditions such as fibromyalgia, chronic pain, chronic fatigue, anxiety and depression?
Utilize existing health records, genomic and epigenomic data to identify factors that predispose or are otherwise associated with the conditions of fibromyalgia, chronic pain, chronic fatigue, anxiety and depression.
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AoU Research Priorities Use Cases
Do epigenetic markers explain secular changes in phenotypes, such as height, intelligence, or obesity?
N/A
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AoU Research Priorities Use Cases
Can GWAS identify the causes of variable expression and progression in Charcot-Marie-Tooth disease?
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AoU Research Priorities Use Cases
Do genomic, epigenetic, and metabolomic characteristics explain the excess risk of type 2 diabetes (T2D) in Asian-Americans?
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AoU Research Priorities Use Cases
Environmental Exposures in the Ohio-Mississippi River Basin: The Missing Link to Obesity
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AoU Research Priorities Use Cases
Which PAIN GENES/PATHWAYS are commonly expressed in patients with ARACHNOIDITIS or low back pain with radiculopathy
1. Identify patients with a diagnosis of arachnoiditis or low back pain with radiculopathy
2. Examine genetic variants, and gene expression and epigenetic status of respective genes
3. Determine if a genetic relationship among respective patient community
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AoU Research Priorities Use Cases
What is the functional mechanism when environmental exposures are associated with human health effects? Vary by age of exposure?
Using biospecimens of persons of varying ages, characterize exposure to environmental chemicals and metals over time and conduct omics studies to identify the functional mechanism of observed health effects - gene expression, metabolomics, epigenetics and genetic variants. Most important, have a plan for integrating the findings of these various studies.
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AoU Research Priorities Use Cases
Are different depression phenotypes associated with different prognosis after myocardial infarction (MI)?
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AoU Research Priorities Use Cases