Fatigue is a ubiquitous symptom commonly reported in people with acute and chronic illness. We do not know the specific underlying mechanisms of fatigue; some studies suggest inflammation, the hypothalamic pituitary adrenal (HPA) axis and the autonomic nervous system are implicated in fatigue. We propose longitudinal assessments of self-reported fatigue and inflammatory biomarkers monthly over 1 year to determine those... more »

Fatigue and daytime sleepiness are commonly reported symptoms. While these are distinctly different concepts, they may share common etiologies and/or mechanisms. Longitudinal assessments of self-reported fatigue and daytime sleepiness along with actigraphy (objective sleep measurements) may allow us to discern those similarities and/or differences between fatigue and excessive daytime sleepiness.

Utilize existing health records, genomic and epigenomic data to identify factors that predispose or are otherwise associated with the conditions of fibromyalgia, chronic pain, chronic fatigue, anxiety and depression.

Autoimmune diseases, such as Sjögren's, manifest themselves in a wide variety of ways in patients. However, a common thread in many of these diseases is fatigue, depression, and cognitive dysfuction, or "brain fog." These physical and mental manifestations can have serious, debilitating, consequences for those who suffer with them. A better understanding of the pathways of these manifestations will allow for a more informed... more »

Fatigue is commonly reported as prodromal to acute and chronic illness. At this point, we do not understand the etiology of fatigue; it is often confused with sleepiness. Longitudinal assessments of self-reported symptoms (fatigue, sleep, pain, depression), comorbid conditions, physical activity, and biomarkers will be collected monthly over 1 year to allow us to assess potential temporal effects of fatigue on daytime... more »