Showing 6 ideas for tag "lower-urinary-tract-symptoms"
(@harlow) kudos icon +

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Is a history of localized provoked or generalized vulvodynia associated with lower urinary tract symptoms (LUTS)?

8% of women may experience stigmatizing and debilitating chronic vulvar pain (vulvodynia) by age 40. Recurrent urogenital infections are associated with vulvodynia and women with vulvodynia may be at risk of LUTS. Vulvodynia patients fail to seek care and therefore we propose to ask women to report any period of pain during intercourse, tampon use, or at the time of a pelvic examination that lasted for at least 3 months... more »

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199 votes
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(@jenna.norton) kudos icon +

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What characteristics define women with Urinary Incontinence who respond to midurethral sling surgery, versus those who don’t?

Midurethral sling surgery (MuSS) outcomes are inconsistent. We lack knowledge of outcome moderators. This study will identify a prospective subcohort of women aged 18+ with incident successful and unsuccessful MuSS. Hypothesized moderators of MuSS outcome spanning the social ecological model (e.g., urinary microbiome, comorbidities, BMI, physical activity, race, occupation, income) will be compared across those with successful... more »

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20 votes
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(@abrsmith) kudos icon +

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Different types of physical activity are associated with an increase or decrease in the risk of urinary symptoms in older adults

Lower urinary tract symptoms (LUTS, eg incontinence, overactive bladder, slow urinary stream) negatively affect quality of life of many individuals as they age, yet some people never experience LUTS. Different types of physical activity (eg walking versus heavy lifting) may protect against or increase the risk of LUTS. We propose to identify people >65 years old, with and without LUTS, and identify how physical activities... more »

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33 votes
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(@jenna.norton) kudos icon +

AoU Research Priorities Use Cases

What characteristics define women with Urinary Incontinence who respond to midurethral sling surgery, versus those who don’t?

Midurethral sling surgery (MuSS) outcomes are inconsistent. We lack knowledge of outcome moderators. This study will identify a prospective subcohort of women aged 18+ with incident successful and unsuccessful MuSS. Hypothesized moderators of MuSS outcome spanning the social ecological model (e.g., urinary microbiome, comorbidities, BMI, physical activity, race, occupation, income) will be compared across those with successful... more »

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10 votes
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(@hhenrylai) kudos icon +

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What are the biological, behavioral and metabolic factors that predict response vs non-response to overactive bladder treatment?

One out of 6 adults in the US (33 millions) and one out of 10 worldwide (546 millions) are affected by overactive bladder (OAB). Despite the high economic cost ($82 billions by 2020), treatment response to OAB remains suboptimal. Using data from over 1 million men and women, we will identify biological (eg, genomics, ethnicity, medical history), behavioral (lifestyle), and metabolic factors (eg, metabolic syndrome, obesity)... more »

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8 votes
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(@hhenrylai) kudos icon +

AoU Research Priorities Use Cases

What are the biological, environmental, and behavioral factors associated with the longitudinal trends of interstitial cystitis?

Interstitial cystitis (IC) is defined by the hallmark symptoms of chronic pelvic or bladder pain, often accompanied by urgency or frequency of urination. Using data from over 1 million men and women, we will examine the natural history and longitudinal trends of IC symptoms over 10 years in a diverse population that are traditionally underrepresented in IC research. We will also examine the biological, environmental,... more »

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6 votes
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