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Why do some previosuly healthy infants and toddlers develop severe lower respiratory tract infections with common viruses?

This would be designed as a prospective observational cohort study of children (infants to 2 year olds) with common seasonal respiratory viral illnesses (RSV, enterovirus/rhinovirus, human metapneumovirus, parainfluenza, influenza). Those with severe bronchiolitis/pneumonia requiring hospitalizations would then be compared to those who receive care as outpatients. The analysis would include clustering based on genetic... more »


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