A transformative goal would be to use precision medicine to individualize and make far more effective dose-response interventions and prescriptions for physical activity and other health behaviors. Methods could include data collection through wearable technology, validated self-reports, other existing health data, and the unique insights from All of Us, especially related to sources and effects of lifestyle influence.... more »

Precision microbiome engineering could be applied to vaccine delivery, immunology, drug-resistant infections, and post-surgical infections.

Specific research questions re pathogenesis and treatment:

- What aspects of the indigenous microbiota mediate colonization resistance against C. difficile, as well as other multi-drug resistant organisms such as carbapenamase-producing gram negative bacteria and vancomycin resistant... more »

To study adult cancer survivors who received cancer therapy during childhood. What are their cardiovascular functions as compared to adults who did not receive cancer therapy. Reduction of cardiovascular functions after anticancer therapy may take years to develop. These undesirable complications can compromise quality of life or shorten life span. This study will provide evidence-based guidelines for physicians to choose... more »

How is precision medicine as it applies to infectious diseases different than how it is considered for Oncology or other fields?

• Time-pressured setting (e.g., initiating therapy for a hospital acquired or ventilator-associated bacterial pneumonia patient)

• Microbiome vs. human genome

• Intersections with other cognitive and procedural specialties across the board

Conduct research to understand the epidemiology of thromboembolism after cancer diagnosis and identify the contributing factors. Thromboembolism can cause treatment dilemma as many anticancer treatments cause thrombocytopenia. Better understanding of the timing and risk factors can provide evidence-based management of cancer patients without the risks of life threatening bleeding or thromboembolism. Possible risk factors... more »