Frequent and urgent urination secondary to obstruction from prostate enlargement may reduce physical activity and adherence to diuretics, thereby increasing metabolic risk profile. This study will identify a prospective subcohort of men with incident surgery to relieve bladder outlet obstruction (BOO). We hypothesize relief of LUTS will decrease need to urinate, increase level of physical activity, and reduce MRP. Patient... more »

For many autoimmune diseases, such as Sjögren's, a lack of clinical, hematological and histological biomarkers has proven to be a hindrance to our understanding, management, and treatment of the disease. This study would focus on identifying such biomarkers in patients with autoimmune diseases to help improve diagnosis, better classify patients, and identify risk factors, and have the potential to show improvement with... more »

SUI may contribute to reduced physical activity and poorer adherence to diuretics, thereby increasing metabolic risk profile. This study will identify a prospective subcohort of women aged 18+ with incident MuSS to compare metabolic risk profile before and after successful surgery. We hypothesize successful MuSS will decrease need to urinate during day, increase level of physical activity, and reduce metabolic risk. Patient... more »

The NIDCD estimates that age related hearing loss, or presbycusis, affects 1 in 3 individuals in the United States between 65 and 74 years old, and nearly half of those older than 75. Despite this large burden, few genetic risk factors have been identified, and it is unclear how genetics and environment interact to influence hearing loss susceptibility. I propose to measure hearing loss progression in the All of Us cohort,... more »

Recent findings from 15,744 black and white adults in the ARIC Cohort Study found that several cardiovascular (CV) risk factors in middle age (smoking, diabetes, prehypertension & hypertension) are linked to higher risk of dementia later in life, and that blacks have higher rates of dementia v. whites. AoU offers ability to evaluate differential associations of specific CV risk factors, & their interactions with other... more »

Ask participants to self-identify "race" as they would be asked on many organizational forms, such as employment, school, and insurance forms.

Examine if DNA of participants correlates with their self-identified "race."

My theory is "race" is a meaningless categorization of most people, but nevertheless people often use social categories without significant correlation with DNA. If true, then the All Of Us data could... more »

The American College of Cardiology/American Heart Association Atherosclerotic Cardiovascular Disease risk score is a well-known and widely used risk score that provides 10-year risk estimates. However, this score does not account for environmental exposures as experienced at a person's primary residence, many of which are strongly associated with cardiovascular disease. Using All of Us we can evaluate if measurements... more »

Chronic stress has significant suppressive impact on the immune system and would influence the risk of infection-associated cancers if high risk infections are allowed to persist. In general populations and healthy adult populations, this question has not been addressed. It would involve serial measurement of oral or anogenital human papillomavirus, or even helicobacter pylori.

Prostate cancer has long been suspected to include an infectious etiology, although no agent has been identified. It is possible that one specific virus or bacterium is not significant, but rather the characteristics of the entire microbiota to which the prostate is exposed (e.g., the abundance and diversity of all microorganisms). This may be capturable by examining the seminal fluid microbiome.