AoU Research Priorities Use Cases
AoU Research Priorities Use Cases
Biomarker identification to help improve diagnosis, identify risk factors, and better classify patients with autoimmune diseases
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AoU Research Priorities Use Cases
Can we identify the reasons for overlapping disease manifestations across high-burden illnesses?
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AoU Research Priorities Use Cases
Can we identify and/or develop better diagnostic tools for Sjögren's and other autoimmune diseases?
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AoU Research Priorities Use Cases
How can we better understand fatigue, depression, and cognitive dysfunction in Sjögren's and other autoimmune diseases?
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AoU Research Priorities Use Cases
Can we find better treatments for neuropathic numbness and pain in Sjögren's and other autoimmune diseases?
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AoU Research Priorities Use Cases
What are the pathogenic mechanisms leading to the development of blood cancers in autoimmune disease patients?
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AoU Research Priorities Use Cases
Can we improve the identification and management of Sjögren's in children?
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AoU Research Priorities Use Cases
Can we find a new class of drugs to successfully treat reflux and GERD without the potentially devastating side effects?
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AoU Research Priorities Use Cases
Can we find better dental restoration materials and improved dental implants that work in a dry mouth?
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AoU Research Priorities Use Cases
Can we better determine which Sjögren's mothers are at risk of having babies with fetal heart block and prevent its occurrence?
It is known that the autoantibody SSA can lead to heart block in the fetuses of mothers with Sjögren's and lupus. However, not everyone who is positive for SSA has a fetus with heart block. This study would focus on fine-tuning the risk factors for fetal heart-block in to improve the odds of preventing its occurrence
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AoU Research Priorities Use Cases
How can we better treat tinnitus and hearing loss as a side effect of hydroxychloroquine and other medications?
Tinnitus and hearing loss can occur as a side effect of hydroxychloroquine and other medications, which are frequently prescribed to treat symptoms of Sjögren's and lupus. This study would focus on identifying how we can reduce the risk of these hearing-related symptoms and investigate potential ways to restore full hearing.
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AoU Research Priorities Use Cases
How can we better address retinal damage related to the use of hydroxychloroquine?
Retinal damage is a serious and feared side effect of hydroxychloroquine, a frequently prescribed treatment for Sjogren's and lupus patients. Though we have sensitive tests and guidelines for monitoring patients on the therapy, more information is needed on how we can reverse the potential progression of damage once it has been detected.