MRI studies would be performed with each MS flare and annually. Patients with lesions in their frontal lobe would complete a questionnaire regarding their mental and emotional state. Caregivers would also complete the questionnaire with their observations of the MS patient. We would expect to see mood disorders and/or depression in MS patients who have lesions in their frontal lobe. Data would be collected for 5 years.... more »

Complex brain networks are responsible for translating thoughts and ideas into sequences of movements that produce the sounds of speech. Any disturbance in these networks can lead to changes in how we speak and what we say. Evidence shows that subtle changes in speech are early harbingers of neurological disease. We propose to use the AoU platform to validate this hypothesis on a large scale and to develop AI tools for... more »