Defining heightened sensitivity as an increased hazard ratio for an association between air pollution and a health outcome, identify subsets of the population based on molecular factors, e.g. genetic variants, hypermethylated regions, which are at increases risk of adverse cardiovascular or pulmonary events during high air pollution days.
Showing 4 ideas for tag "air-pollution"
The goal would be to examine the associations between multiple environmental stressors (air pollutants, temperature, etc) on chronic disease risk, and how these associations are modified by inherent characteristics, lifestyle factors, and the built and natural environments. This would require current & historical residential/work addresses and appending environmental data. This would provide more information on how these... more »
The American College of Cardiology/American Heart Association Atherosclerotic Cardiovascular Disease risk score is a well-known and widely used risk score that provides 10-year risk estimates. However, this score does not account for environmental exposures as experienced at a person's primary residence, many of which are strongly associated with cardiovascular disease. Using All of Us we can evaluate if measurements... more »
Previous research has suggested that women who live in areas with high levels of outdoor air pollution may have a higher risk of breast cancer. We suggest collecting data on participants’ current and previous residence(s) and place(s) of work in order to link geographic location to existing air quality databases. Data collection would be facilitated through map features allowing on-the-go geocoding. Outcome data would... more »