This study will focus on a subsample of all pregnant women and follow them throughout pregnancy to obtain serial assessments and measurements, including laboratory microbiologic evaluation testing of oral, skin and vaginal specimens. Follow-up would end at delivery of the infant; serial pregnancies would be eligible to re-enroll. Assessments and measures would be used along with health outcomes to determine associations... more »

Follow a subsample of all infants and children (< 3 years of age) throughout childhood to obtain the following serial assessments: blood tests, medication history, neonatal, infant and childhood health outcomes; physical measurements and laboratory microbiologic evaluations of oral, skin and vaginal specimens. Assessments and measures would be used along with health outcomes to determine associations and develop predictive... more »

This study will focus on the entire cohort of children (infants-18 y/o) and will identify those risk factors which predispose children to sepsis. The information will be used to create more precise strategies to identify individuals at highest risk of sepsis and to implement preventive or early treatment therapies that would improve outcomes. The study will also assess the use of adjunctive immunomodulatory therapies... more »

Use food sensitivity testing- blood, saliva, stool samples. Track food, stool types and compare to food sensitivities. Eliminate sensitive foods from diet and track. Determine additions to diet to rebuild healthy microbiomes in the gut e.g. supplements, vitamins, probiotics or stool transplants, eliminate use of antibiotics. The goal would be to create individualized nutritional plans to improve gut health, lose weight,... more »

Antibiotics have long been the standard of care for treatment of urinary tract infections (UTI). However, UTI may be successfully managed without antibiotics, thereby reducing unnecessary contributions to antibiotic resistance. We proposed to compare outcomes (e.g., pyelonephritis, sepsis, GI distress/ diarrhea) in individuals with UTI treated with and without antibiotics, controlling for potential confounders (infection... more »