This study will focus on women who are pregnant at enrollment or become pregnant during the study and the offspring of observed pregnancies. The information will help to define genetic and epigenetic predictors of long-term effects of common pregnancy complications.

Cannabis use is increasing with greater legalization; data on health consequences are limited. AllofUs could enable a comprehensive study of health impacts of cannabis use. Sufficient questions to characterize past and current use of the range of cannabis products would need to be added. Health outcome data from questionnaires and medical record linkage already being collected could be used. Existing biospecimens could... more »

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This study will enroll premature infants at the time of birth, in order to follow the children in phases from birth to adulthood to test the central hypothesis that premature birth permanently impairs normal pulmonary and cardiovascular development, resulting in the development of common and rare cardiopulmonary conditions which reduce cardiopulmonary function throughout life. Phase one will study children from birth... more »

Following AoU participants for decades could uncover common trajectories of body mass index (BMI) across lifespan and their associations/impact on cardiovascular diseases (CVD). AoU’s size/diversity also enables precise measure of the associations by different subgroups (e.g., race, sex, social factors, presence of multiple risk factors). The findings could further shed light on optimal timing for initiating and/or intensifying... more »

People who smoke or have hypertension, diabetes, and hyperlipidemia are at increased risk of developing cardiovascular diseases (CVD). However, not all do, and it would be interesting to identify those with CVD risk factors but remain free of CVD. Studying these people phenotypically, genomically, environmentally, and molecularly (via -omics) could provide great insight into novel mechanisms by which new treatments... more »

Are there depression (MDD) phenotypes that have different genomic, biological, and psychological underpinnings, which we should be treating differently? Utilize an acute post-MI sample stratified by non-MDD, prior history of MDD, or new MDD. Then stratify all MDD by treated-success-MDD, treatment-resistant depression, and not treated. Examine mortality and cardiovascular event recurrence among non-MDD and MDD types,... more »

Following AoU participants for decades could uncover common trajectories of BP across lifespan and their associations/impact on cardiovascular diseases (CVD). AoU’s size/diversity also enables precise measure of the associations by different subgroups (e.g., race, sex, social factors, presence of multiple risk factors). This could lead to refined risk predictions for CVD and further shed light on optimal timing for initiating... more »

Women with specific pregnancy complications including poor fetal growth, preterm birth and preeclampsia may have an increased risk of later cardiovascular disease. Studies based on birth certificate data cannot include women with no births, through choice or infertility. A population based study will allow inclusion of all women and provide data on all pregnancy outcomes, not just births. Post-partum interventions or... more »

The American College of Cardiology/American Heart Association Atherosclerotic Cardiovascular Disease risk score is a well-known and widely used risk score that provides 10-year risk estimates. However, this score does not account for environmental exposures as experienced at a person's primary residence, many of which are strongly associated with cardiovascular disease. Using All of Us we can evaluate if measurements... more »