Exposure to air pollutants in the ambient (indoor and outdoor) environment is associated with numerous adverse health outcomes, including cancer. A key challenge for cancer studies is the lack information on individual-level activities and other determinants of personal exposures over the lifetime; existing studies have had to rely on assumptions about time spent in microenvironments. Moreover, most data are from urban... more »

A cohort of asthma patients (who believe they have a pollen allergy) would undergo genetic testing to identify genetic markers. Those patients would undergo blood and skin allergy testing to confirm the allergy, and then the patients would be utilize a mobile monitor to track the weather and environmental exposures (esp. pollen) that are causal to asthma incidences. With a more complete picture of pollen allergen impacts... more »

Epidemiological studies and anecdotal reports suggest an association between certain neurological diseases (e.g. Parkinson's, Alzheimer's, ALS, various neurodevelopmental disorders) and chemical exposures (pesticides,metals, endocrine disruptors) via residential, occupational, and other activities. The study, using genetic information captured could also possible shed light on Gene-Environment interactions as well.

Careful and extensive characterization of lifetime environmental exposures and chronic disease phenotypes in the All of Us population; determination of genetic risk factors for various exposure and disease combinations; follow-up for chronic disease outcomes.

I think the root cause of the obesity epidemics in the Mid-South USA is linked to the NUTRIENT POLLUTION OF THE OHIO-MISSISSIPPI RIVER BASIN, in particular the run off of agricultural fertilizers (nutrient enrichment). These rivers run across the states most affected by obesity. I recommend to measure environmental exposures - chemical (i.e. phosphorus) and biological toxins (i.e. microsystin, cyanotoxins) and measure... more »

To understand health effects of the exposome, exposure assessment in population-based research should include measures of all the exposures of an individual in a lifetime, including general external, specific external, and internal. Assessing the exposome requires multiple, repeated longitudinal and hierarchical exposure measurements with sufficient variability; standardized methodology and analysis; and capabilities... more »

Some individuals are more susceptible or resistant to the health effects of certain environmental exposure for unknown reasons. It is likely that a combination of elements, such as genetic variation, microbiome differences, life stage, or the combined impact of multiple factors (such as diet) contribute to these differences. Mapping the multiple interactions between exposure and response requires the unprecedented power... more »

Currently, environmental exposure monitoring measure classic or persistent chemical exposures, but might fail to analyze newer chemicals. Many newer chemicals are high production volume, but are nevertheless not assessed in population or in study-targeted analyses, but may, in fact, be associated with risk to human or animal health. New personal wearable silicone band monitoring devices, such as those designed Dr. Kim... more »

Most of us spend a lot of time at work. Workplace physical and chemical hazards as well as organizational attributes of the job can have a profound impact on health. While work-related acute injuries and illnesses may be easy to recognize, the effects of work on chronic disease are more difficult to assess. Collecting occupational history and exposure information from the All of Us cohort will help us better understand... more »

Sophisticated laboratory techniques can now extract levels of exposure to numerous trace organic and inorganic contaminants and medications in the layers of tooth enamel- giving timestamped exposure (temporal) sensitivity. This represents a massive step forward because recall, or chronic measurement of place and exposure is not necessary, but is nevertheless important in defining exposure-outcome relationships. Participants... more »

Biological, psychological & social domains interact at multiple levels (genes, human & environment microbiomes, stress, behavior, broad SES & environment) outlined by the biopsychosocial ecological model (BPSEM). The BPSEM specifies pathways aligned with the AoU pillars of biology, lifestyle, & environment. Simultaneous examination of the interacting domains and levels of the BPSEM is now computationally possible and... more »