Severe maternal morbidities are rare, but increasing in the U.S., and the causes and long-term consequences are poorly understood. All of Us would provide a study population with enough participants, detail, and follow-up time to thoroughly investigate how complications during pregnancy, delivery, and postpartum affect future health in women and their children to inform prevention of negative outcomes, such as cardiovascular... more »

Up to 8% of pregnant women take an antidepressant, but we do not understand the long-term effects on brain development and childhood mental illness. A cohort of young adults (16-21) would be assessed for psychiatric illness, in utero medication exposure would be recorded (with emphasis on antidepressants) and potential confounders such as intellectual/physical disability, adverse childhood experiences, family hx, etc... more »