Suicide is a leading cause of death and rates have not decreased in decades. Currently there are no established risk factors that have demonstrated usefulness in predicting individual risk. The All of Us program is in a position to change this by leveraging the large and varied data that will be collected. Making progress in this area would be a major advance and could have a tremendous impact on the suffering that individuals... more »

Given the limited effects of current interventions to prevent preterm birth, it seems likely that the stage for adverse pregnancy outcomes is set even before the pregnancy begins. The All of Us cohort, if sufficient reproductive-aged women are enrolled, would be in a position to examine social, behavioral, medical, and biological/molecular predictors of preterm birth and its subtypes.

When people near the end of their lives, they face many challenging decisions. Mental health symptoms, such as depression and anxiety, could influence how people make those decisions. Research in this area could investigate how mental health symptoms influence decision making at the end of life and how interventions that address those symptoms might enhance decision making.

Communication technologies allow for a better understanding of social networks, yet they are underutilized in the mental health context. AoU provides an opportunity to consider how communication technologies can help promote physical and mental health.

Black Therapists Rock engages over 19,000 psychotherapists who work with vulnerable populations. We have noticed a correlation of improved health outcomes in clients who have utilized Internal Family Systems (IFS), a psychotherapy model that focuses on healing the emotional wounds developed in childhood. We wish to expand upon this data, by employing more therapists to use this model, while advocating/recruiting participants... more »

Too many people have comorbid brain disorders. Not enough is known each disease independently, what causes them and what, if anything, contributes to resilience in the rest of us who do not suffer from them. Research on familial links, people with similar comorbid brain disorders, genetics that play into who gets these diseases and how individuals react uniquely to medications can all lead us to a better understanding,... more »

The impact of psychosocial stress on child and adult health risk is increasingly appreciated. The measurement of this exposure is currently poor, and All of Us has the opportunity to develop or refine wearable technologies that could help push this field of research forward in a valid way for the future. Such technology could be a part of individual studies of stress and disease, and could also be used as a gold standard... more »

The impact of psychosocial stress on child and adult health risk is increasingly appreciated. The measurement of this exposure is currently poor, and All of Us has the opportunity to develop or refine biomarkers that could help push this field of research forward in a valid way for the future. Such biomarkers could be a part of individual studies of stress and disease, and could also be used as a gold standard to develop... more »

Acquire sensor data from mobile phones (e.g. GPS, accelerometry, sound features, light,etc.) and other ubiquitous devices. Collect information on behaviors, psychological states, and environmental conditions through experiencing sampling or other data bases (e.g. weather, mapping services, etc). Develop models that can use the passively collected data to estimate behaviors and psychological states related to the mental... more »

The built environment is only one contextual exposure of interest to investigators who study these factors in relation to disease (and even these function variably across rural and urban areas). New technology could assist in better clarifying a fuller scope of residential exposures, including what elements/exposures the All of Us participants actually come into contact with.

More than 1 in 5 Americans meet lifetime criteria for alcohol use disorder and 1 in 10 Americans meet lifetime criteria for a drug use disorder. Most individuals never seek treatment and most reduce their alcohol or drug use in the absence of treatment. Research on the biological, psychological, and social risk factors for developing and recovering from alcohol/drug use disorders is critical. Annual assessments of DNAm,... more »