Temporomandibular joint disorder (TMD), is a group of conditions that cause pain and dysfunction in the jaw joint and muscles that control jaw movement. The 2014 US National Health Interview Survey reported 4.6% of adults reported pain in the face or jaw in the previous 3 months. TMD often overlaps with other pain disorders, including headache, low back pain, and chronic widespread pain. Identification of genes and gene... more »

Identify subsets of All of Us participants with chronic pain of various types. Administer questionnaire that asks in general about coping mechanisms, self-perceived pain tolerance, interference of pain disorder with function, child and adult exposures to adverse life experiences, history of depression/PTSD, drivers of decision of whether or not to treat an episode of pain, use of pharmacological therapies, use of non-pharmacological... more »

Peripheral neuropathies are common in Sjögren's and related autoimmune diseases and can be a presenting symptom of Sjögren's. Burning pain and numbness in the extremities, trigeminal neuralgias, weakness, poor balance and altered gait can occur. Symptoms can interfere greatly with quality of life and function. This study would focus on identifying better treatments to address these symptoms in Sjögren's and autoimmune... more »

Investigate the correlation between the incidence of reported pain and various social and biological characteristics.
Investigate the correlation between the incidence of reported pain and dietary factors including foods, food additives such as dyes, preservatives and other additives.
Investigate the correlation between the incidence of reported pain and environmental exposures including pollution, pesticides and the... more »

Utilize existing health records, genomic and epigenomic data to identify factors that predispose or are otherwise associated with the conditions of fibromyalgia, chronic pain, chronic fatigue, anxiety and depression.

Goal: determine the effect of regular and structured exercise on pain levels in individuals with sickle cell disease.
Method: RCT with a group who perform at least 150 mins a week of moderate physical activity eg 30 mins of weight lifting 5days/week
Track daily pain levels using numeric pain rating scale from individuals in the exercise group, and the control. Can also track pain episodes and crises per individual, and... more »

This study will focus on the entire cohort ages 50 or older and provide outcomes on bisphosphonate use and movement. The information will help to develop more precise strategies to target individuals who would benefit from bisphosphonates or other interventions for the prevention of bone fractures.

1. Identify patients with a diagnosis of arachnoiditis or low back pain with radiculopathy

2. Examine genetic variants, and gene expression and epigenetic status of respective genes

3. Determine if a genetic relationship among respective patient community

If meditation training is provided before a planned painful procedure, and practiced, can it decrease the amount of analgesia needed to achieve comfort after the procedure has been performed? Patients should be offered meditation training anticipating a planned procedure and have them practice the technique for at least a week prior to the procedure. (Ideally they would not be in pain while being taught or practicing.)... more »

Black Therapists Rock engages over 19,000 psychotherapists who work with vulnerable populations. We have noticed a correlation of improved health outcomes in clients who have utilized Internal Family Systems (IFS), a psychotherapy model that focuses on healing the emotional wounds developed in childhood. We wish to expand upon this data, by employing more therapists to use this model, while advocating/recruiting participants... more »

Interstitial cystitis (IC) is defined by the hallmark symptoms of chronic pelvic or bladder pain, often accompanied by urgency or frequency of urination. Using data from over 1 million men and women, we will examine the natural history and longitudinal trends of IC symptoms over 10 years in a diverse population that are traditionally underrepresented in IC research. We will also examine the biological, environmental,... more »

A randomized controlled study to determine if the combination of ultra-low-dose naltrexone with an opioid can provide better psychosocial outcomes for chronic pain patients. It would compare the results of treatment with various common opioids both alone and in combination with ultra-low-dose naltrexone. The goal is to see which treatment yields the best psychosocial outcomes and pain relief. Preliminary studies suggest... more »

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Sacroiliac joint (SIJ) pain, an elusive generator of lower back pain (LBP), affects 10-30% of lumbar patients with nonradicular pain. However, there is no diagnostic indicator that can be used as a reliable tool to screen SIJ pain. This prospective study uses a pre-operative bilateral injection, targeting a goal to develop a diagnostic tool to screen the incidence of SIJ problems. Expected outcome(s) is this procedure... more »

Stress urinary incontinence (SUI) is prevalent among women, yet the standard of care treatment – midurethral mesh sling – can lead in devastating mesh complications (dyspareunia that precludes sex, chronic pelvic pain, infection). Using national data, we will identify biological (eg, genomics, vaginal & urinary microbiome, race, comorbidities, metabolic syndrome) and behavioral (eg, smoking, physical activity) factors... more »