Frequent and urgent urination secondary to obstruction from prostate enlargement may reduce physical activity and adherence to diuretics, thereby increasing metabolic risk profile. This study will identify a prospective subcohort of men with incident surgery to relieve bladder outlet obstruction (BOO). We hypothesize relief of LUTS will decrease need to urinate, increase level of physical activity, and reduce MRP. Patient... more »

Both Genital HSV 2 infection and prostate cancer are prevalent diagnoses.

The proposed study would answer the question if HSV genital infection in males increase prostate cancer

Prostate cancer has long been suspected to include an infectious etiology, although no agent has been identified. It is possible that one specific virus or bacterium is not significant, but rather the characteristics of the entire microbiota to which the prostate is exposed (e.g., the abundance and diversity of all microorganisms). This may be capturable by examining the seminal fluid microbiome.

Although prostate cancer is the most common cancer among men in the U.S., many men have indolent tumors that are unlikely to cause death in a man’s lifetime. Determining which prostate tumors are likely to lead to death is of critical clinical importance to prevent unnecessary treatment and unwanted side-effects. Understanding factors related to disease etiology and progression and developing risk models is essential... more »