AoU Research Priorities Use Cases

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Showing 18 ideas for tag "social-determinants-of-health"
(@drirene) kudos icon +

AoU Research Priorities Use Cases

Could the Precision Medicine Initiative Reduce Social Inequality?

The proposed study would identify microbial communities and metabolic profiles associated with stigmatized conditions such as idiopathic malodor or mental health.
Working with systemic malodor/PATM community provides unprecedented opportunities to explore biomarkers of depression, social stress, diabetes, inflammatory diseases, dental, cardiovascular, and digestive health, exposure to antibiotics, lifestyle & dietary... more »

Voting

219 votes
Ideate
(@qtnguyen) kudos icon +

AoU Research Priorities Use Cases

What neighborhood conditions promote health?

This project would examine contextual factors that may influence the health outcomes of individuals. Contextual factors include social environment factors (such as social cohesion, crime) and built environment factors (green space, mixed land use, access to healthy food and clinical services). These factors can help or hinder individuals from achieving or maintaining health. Outcomes of interest include obesity, diabetes,... more »

Voting

45 votes
Ideate
(@jenna.norton) kudos icon +

AoU Research Priorities Use Cases

What characteristics define women with Urinary Incontinence who respond to midurethral sling surgery, versus those who don’t?

Midurethral sling surgery (MuSS) outcomes are inconsistent. We lack knowledge of outcome moderators. This study will identify a prospective subcohort of women aged 18+ with incident successful and unsuccessful MuSS. Hypothesized moderators of MuSS outcome spanning the social ecological model (e.g., urinary microbiome, comorbidities, BMI, physical activity, race, occupation, income) will be compared across those with successful... more »

Voting

20 votes
Ideate
(@jaime.hart) kudos icon +

AoU Research Priorities Use Cases

How do exposures to multiple environmental stressors impact chronic disease risk

The goal would be to examine the associations between multiple environmental stressors (air pollutants, temperature, etc) on chronic disease risk, and how these associations are modified by inherent characteristics, lifestyle factors, and the built and natural environments. This would require current & historical residential/work addresses and appending environmental data. This would provide more information on how these... more »

Voting

27 votes
Ideate
(@rebeheart) kudos icon +

AoU Research Priorities Use Cases

Develop a Social-Determinants-of-Health risk calculator for chronic disease development (cardiovascular, Type 2 Diabetes, etc)

Which social determinants of health (SDH) or what combination carry the greatest risk for the development of top chronic diseases?Developing a SDH risk calculator can guide clinical practice, community resource allocation, and prevention efforts. Use evidence-based SDH variables to develop a predictive model for 10yr risk of developing most common chronic diseases. Test model in a diverse sample <18 years of age over... more »

Voting

22 votes
Ideate
(@ginawei) kudos icon +

AoU Research Priorities Use Cases

What are the impact of common environmental exposures on cardiovascular (CV) and other health outcomes?

We are constantly exposed to environmental exposures such as air pollution, allergens, and man-made chemicals. AoU offers a unique opportunity to collect such exposures both passively (e.g., linking to local environmental data) and actively (e.g., using novel mHealth devices to measure new data from individual AoU participants). These can be overlaid with behavioral, clinical, genomics, and biological data in AoU to assess... more »

Voting

19 votes
Ideate
(@jenna.norton) kudos icon +

AoU Research Priorities Use Cases

What characteristics define women with Urinary Incontinence who respond to midurethral sling surgery, versus those who don’t?

Midurethral sling surgery (MuSS) outcomes are inconsistent. We lack knowledge of outcome moderators. This study will identify a prospective subcohort of women aged 18+ with incident successful and unsuccessful MuSS. Hypothesized moderators of MuSS outcome spanning the social ecological model (e.g., urinary microbiome, comorbidities, BMI, physical activity, race, occupation, income) will be compared across those with successful... more »

Voting

10 votes
Ideate
(@ginawei) kudos icon +

AoU Research Priorities Use Cases

Leverage All of Us to advance research in social determinants of health (SDH): Toward a personalized definition of SHD

Healthy People (HP) 2020 defines social determinants of health (SDH) as “conditions in the environments in which people live, learn, work, play, worship, and age that affect a wide range of health, functioning, and quality-of-life outcomes and risks.” AoU can capture this data on their 1 million+ participants and address many unanswered questions, including: Can more personalized definitions of SHD be developed that... more »

Voting

14 votes
Ideate
(@atrenthamd) kudos icon +

AoU Research Priorities Use Cases

Exposures to environmental chemicals during pregnancy and effects on epigenetic biomarkers of metabolic syndrome and obesity

Obesity and breast cancer are leading cause of morbidity and mortality. Evidence strongly suggests that certain periods of life, including those during fetal development and pregnancy, influence risk of breast cancer later in life. Environmental chemicals may increase breast cancer risk-especially during pregnancy-by mimicking estrogen and other hormones. Epigenomic signatures present in the placenta uniquely capture... more »

Voting

9 votes
Ideate
(@sxm270) kudos icon +

AoU Research Priorities Use Cases

What is the impact of time-varying, place-based social determinants of health measures on physical and mental health

To answer important physical and mental health questions we need to understand the trajectory of the individuals and the trajectories of the places they have lived (residential histories). If exposure equals space x time (over the life courses) we need data on the timing, sequence and duration of residence in specific contexts (places). How we define/measure place is important for (retro)prospective work and will enables... more »

Voting

6 votes
Ideate
(@jpcastner15) kudos icon +

AoU Research Priorities Use Cases

What are the multi-level, environmental exposure endotype pathways of autoimmune inflammation and disease? Reactive airway?

Focusing recruitment on communities with a disproportionate burden of environmental exposures, develop and test a multi-level model to ascertain the burden of autoimmune inflammation, autoimmune disease, and reactive airway attributable to environmental factors at the 1) community/neighborhood, 2) household, 3) personal, 4) internal body burden, and 5) inflammatory biomarker response levels over time. Ascertain how genetic... more »

Voting

7 votes
Ideate
(@wendyblacksburg) kudos icon +

AoU Research Priorities Use Cases

role of societal level factors in understanding heart disease

There are strong areal relationships with the rate of heart disease. the Allofus design can help distinguish individual genetic risk and behaviors from the role of social factors. it is essential, however, that the data set include sufficient areal data and information (such as zip code and census track) to support such analyses. The information that links to societal level data needs to be collected repeatedly and... more »

Voting

4 votes
Ideate
(@jpcastner15) kudos icon +

AoU Research Priorities Use Cases

What are the health effects of sustained ambient exposure above state/fed health-based annual guideline concentrations?

For communities that have sustained (1+ years) ambient and community exposure levels above EPA and/or state environmental agency health-based annual guideline concentrations (e.g. US vs. Tonawanda Coke 10-CR-219-S with increased residential neighborhood levels of PAH's and aldehydes). For these communities seeking research on the increased relative risk of rare disease outcomes, like leukemia, best served by the scale... more »

Voting

4 votes
Ideate