AoU Research Priorities Use Cases
AoU Research Priorities Use Cases
How reliably do epigenetic aging clocks predict disease onset and mortality? Can they be slowed or reversed?
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AoU Research Priorities Use Cases
Role of Persistent Co-infections in Health and Disease
Co-infections can significantly alter disease risk, incidence, prevalence, aggressiveness, treatment response and outcomes, in addition to, making it more difficult to manage and treat the diseases. Compare differences in host response to co-infections, disease risk and treatment response to elucidate how the ubiquitous co-infections contribute to variations in disease incidence and outcomes.
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AoU Research Priorities Use Cases
What are the pathogenic mechanisms leading to the development of blood cancers in autoimmune disease patients?
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AoU Research Priorities Use Cases
What are the long-term cardiovascular effects of cancer therapy? Do childhood cancer survivors have reduced cardiac functions?
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AoU Research Priorities Use Cases
Evaluate Age-related Microbiota Changes and their impact in Health, and in Chronic Disease Prevention, Treatment and Progression
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AoU Research Priorities Use Cases
Use genetic sequencing to Identify what factors account for some individuals to live to 100 years without developing canc
Survey those individuals as to their life experiences - medical history, employment history, lifestyle, exercise history, diet etc
Individuals will provide a blood sample for complete genetic analysis.
What genetic mutations are present which may cause cancer yet... more »
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AoU Research Priorities Use Cases
Develop and validate simple user friendly modalities to reduce patient wait times to improve cancer survival and outcomes
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AoU Research Priorities Use Cases
What are the genetic, comorbid risk factors, and anticancer agents that contribute to heart failure after cancer therapy
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AoU Research Priorities Use Cases
Does data from deep sequencing tumors (personalized medicine) allow for targeted treatment and better survival of patients?
2. Perform the "clinical" trial. Use the deep sequencing as a diagnostic to aid in planning the treatment for a set of 50-100 patients for a given type of cancer. Track the outcomes: survival time,... more »
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AoU Research Priorities Use Cases
What is the role of neuroendocrine-immune system role in cancer initiation, progression and metastasis?
Little is known about the nervous system's role in cancer. Interplay of neural and immune system pathways may play an important role in cancer.
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AoU Research Priorities Use Cases
What is the long-term impact of consumption of organic foods on health outcomes?
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AoU Research Priorities Use Cases
Will the All if Us data compilation and subsequent research be used to treat and eradicate renal medullary carcinoma?
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AoU Research Priorities Use Cases
Can we build precise cancer risk prediction models that may guide early diagnosis
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AoU Research Priorities Use Cases
Conduct research to determine if blood can help identify the presence of the HPV-16 virus.
Methodology:
- Include people diagnosed with oral and oropharyngeal cancer caused by the HPV-16 virus
- Collect and analyze blood every 3 months within the first 2 years of diagnosis. Between 2 and 5 years do it every 4 months
Outcome: increase the survival rate. The death rate is about 43% at five years from diagnosis. When found at... more »