Tobacco and alcohol use and persistent oral infection with human papillomavirus (HPV) are risk factors for oral cancer (OC) and oropharyngeal cancer (OPC). CDC estimates that approximately 60% of OPC cases in the United States are caused by HPV types 16/18. Previous studies (GWAS) suggest genetic factors are associated with an increased risk of developing HPV-related OPCs. Assessing genetic factors in a large population... more »

An annual blood test with analysis of methylation sites from key epigenetic aging clocks (e.g. Horvath). Epigenetic aging clocks have already been shown to reliably predict age, time-to-death, all cause mortality, cog. function, immune function, CV disease, cancer, and more. They may also become a key tool to demonstrate the reversibility of disease risk through dietary and therapeutic regimens, as epigenetic states are... more »

Co-infections can significantly alter disease risk, incidence, prevalence, aggressiveness, treatment response and outcomes, in addition to, making it more difficult to manage and treat the diseases. Compare differences in host response to co-infections, disease risk and treatment response to elucidate how the ubiquitous co-infections contribute to variations in disease incidence and outcomes.

Patients with autoimmune diseases have been found to be at a higher risk of certain types of cancers, particularly hematologic cancers. A recent study found that patients with Sjögren's were eleven times more likely to develop a hematologic cancer compared to patients without Sjögren's. The purpose of this study is to identify the pathogenic mechanisms leading to the development of blood and other cancers in patients... more »

To study adult cancer survivors who received cancer therapy during childhood. What are their cardiovascular functions as compared to adults who did not receive cancer therapy. Reduction of cardiovascular functions after anticancer therapy may take years to develop. These undesirable complications can compromise quality of life or shorten life span. This study will provide evidence-based guidelines for physicians to choose... more »

The microbiome variations have been associated with health and disease status in cross-sectional studies. There is a need to examine these associations in a longitudinal fashion and to establish baseline changes in health and disease over a lifespan. All of Us Together provides a game-changing amount of longitudinal data on enough individuals to begin to map the complex relationship between exposures (diet, antibiotics,... more »

Identify the population of individuals who are age 100 years half who may have had a cancer diagnosis and half with no cancer diagnosis in their lifetime.
Survey those individuals as to their life experiences - medical history, employment history, lifestyle, exercise history, diet etc
Individuals will provide a blood sample for complete genetic analysis.
What genetic mutations are present which may cause cancer yet... more »

Mobile health platforms may be developed and validated to reduce patient wait times between primary care physician's referral and obtaining appropriate care from a specialist. The modalities may navigate patient in the identification of a specialist, making appointment with the specialist(s), facilitate faster diagnostics and treatment decisions, increase access to needed care, improve patient adherence to treatment and... more »

Goals:To study the epidemiology of cardiovascular complications of cancer therapy in order to design prevention strategy and precision treatment of cancer patients while minimizing debilitating cardiovascular complications. Methods: compare data on genetic, co morbid risk factors, and anticancer agents used in association with cardiovascular complications after cancer therapy. Expected outcomes: This study will provide... more »

1. Divide "cancer" into multiple classes (ie breast, lung, pancreatic, etc.) and sequence tumors from 50-100 patients undergoing treatment. As with breast cancer, identify markers aligning with specific treatments and outcomes.
2. Perform the "clinical" trial. Use the deep sequencing as a diagnostic to aid in planning the treatment for a set of 50-100 patients for a given type of cancer. Track the outcomes: survival time,... more »

Little is known about the nervous system's role in cancer. Interplay of neural and immune system pathways may play an important role in cancer.

Organic foods are thought to be healthier than conventional foods because of the limited exposure to pesticides and other chemicals. Few studies have examined the long-term health effects of organic foods. By collecting information on organic food consumption and comparing those who tend to consume more organic foods (e.g., organic fruits/veg) to those who consume less, we could evaluate the impact of organic food consumption... more »

I have a cousin who is undergoing chemotherapy for renal medullary carcinoma, a cancer specific to patients with sickle cell. Aside from the fact that we need to discover a means of eradicating sickle cell from our planet, will the All of Us program be used to further research into the development of better treatment options for patients who develop this cancer? The pool of candidates is very small due to rarity of the... more »

The early detection of cancer improved treatment outcomes and patient survival. Building precise risk prediction models can personalize cancer screening programs to ones need. The integration of variables capturing changes in lifestyle factors, exposure history, and molecular markers overtime, together with the opportunity for passive surveillance through data linkage to electronic medical records and cancer registries... more »

Goal: save millions of lives. A person dies from oral cancer every hour of every day.
Methodology:
- Include people diagnosed with oral and oropharyngeal cancer caused by the HPV-16 virus
- Collect and analyze blood every 3 months within the first 2 years of diagnosis. Between 2 and 5 years do it every 4 months
Outcome: increase the survival rate. The death rate is about 43% at five years from diagnosis. When found at... more »