This study will focus on the entire cohort of children (infants-18 y/o) and will identify those risk factors which predispose children to sepsis. The information will be used to create more precise strategies to identify individuals at highest risk of sepsis and to implement preventive or early treatment therapies that would improve outcomes. The study will also assess the use of adjunctive immunomodulatory therapies... more »

Which social determinants of health (SDH) or what combination carry the greatest risk for the development of top chronic diseases?Developing a SDH risk calculator can guide clinical practice, community resource allocation, and prevention efforts. Use evidence-based SDH variables to develop a predictive model for 10yr risk of developing most common chronic diseases. Test model in a diverse sample <18 years of age over... more »

The window of opportunity for disease prevention in at-risk individuals may be before symptoms occur and blood/urine chemistries indicate a problem. Considering that one’s metabolome reflects both genetic and environmental influences, could metabolite profiles be explored in the All of Us biospecimens and assessed as diagnostic tools?

We propose to investigate risk of developing cancer in a cohort of 100,000 AoU participants using NCIs Activities Completed over Time in 24-hours (ACT24) recall system (doi.org/10.1249/MSS.0000000000001428), and research grade accelerometers. Cases of incident cancer will be captured via linkage to state cancer registries.