Economic and sociological drivers impact access to individualized specialty health care. This study would examine the role of age (pediatric, geriatric), gender, or ethnicity specialty expertise on patient outcomes. Demographic information would be combined with survey information about access to specialty medical care expertise. Outcomes would be determined by PPI and EHR, to include admissions, length of stay, disability... more »

This study will focus on the entire cohort. The goal will be to determine the interaction of genomic, sociodemographic, physiologic and environmental factors for the mother and child impacted by Neonatal Opioid Withdrawal Syndrome (NOWS) and their impact on treatment response, treatment outcome, health outcomes for the mother, and developmental outcomes for the child.

To study genotype-phenotype correlations, utilize measures targeting the Broader Autism Phenotype: social and communication scales (SRS), Connors Rating Scale for ADHD, ratings of depressive symptoms (PHQ-9), anxiety disorders, & adverse childhood experiences (ACEs) & traumatic life events. Children transitioning to adulthood during the study will have repeat assessment of function and mental health status at a later... more »

Biomarkers of sleep sufficiency need to be developed for use in safety for duty and also for use as longer term health indices.

We are all at risk of losing our sense of smell -- from upper respiratory infection, head injury, to simple aging. Those with anosmia/hyposmia have nutritional imbalances because the sensory aspects of food intake are reduced. Anosmics report anxiety and danger from food poisoning, fire, gas, and other environmental threats detected by the sense of smell. Over 10 million Americans experience loss of smell and we as a... more »

This would be a long term survey done on participants who would fill out a survey given to them quarterly with their self reported answers. Over many years they would have their exercise routine tracked. The amount of exercise they do, the type of exercise they do, the time they spend doing it would then be compared to the general public as far as the participants lengthening their lives, decreasing their cancer risk,... more »

Co-infections can significantly alter disease risk, incidence, prevalence, aggressiveness, treatment response and outcomes, in addition to, making it more difficult to manage and treat the diseases. Compare differences in host response to co-infections, disease risk and treatment response to elucidate how the ubiquitous co-infections contribute to variations in disease incidence and outcomes.

Cannabis use is increasing with greater legalization; data on health consequences are limited. AllofUs could enable a comprehensive study of health impacts of cannabis use. Sufficient questions to characterize past and current use of the range of cannabis products would need to be added. Health outcome data from questionnaires and medical record linkage already being collected could be used. Existing biospecimens could... more »

The microbiome variations have been associated with health and disease status in cross-sectional studies. There is a need to examine these associations in a longitudinal fashion and to establish baseline changes in health and disease over a lifespan. All of Us Together provides a game-changing amount of longitudinal data on enough individuals to begin to map the complex relationship between exposures (diet, antibiotics,... more »

Sleep (quantity, quality, timing), sedentary behavior, and physical activity of various intensities, affect each other and many health outcomes. Health conditions affect individuals’ sleep and activity patterns. Capturing 24-hour device data repeatedly will allow exploration of multiple hypotheses about sleep, sedentary behavior, physical activity and health. Longitudinal data will allow exploration of causality in both... more »

What role does perceived and/or factual evidence of LOVE of others, oneself, and received by others play in health/epidemiology?

Goals and outcomes of methods would be to develop statistically reliable and valid longitudinal measures of the negative and beneficial manifestations of real or perceived love of oneself and also from others on personal health outcomes and on population based epidemiology using a large random... more »

I would like to do a longitudinal study of patients that utilize patient portals and those that do not. This would be a continuous assessment of the cost of healthcare, the number of tests given, outcomes, and overall health assessment for individuals of similar demographics and health statuses. Does the increase in availability of information cause a positive, negative, or an unnecessary impact on the patient's health... more »

Most research is devoted understanding factors which increase disease risk. Here we specifically seek to find individuals who are healthy despite exposure to high levels of environmental pollutants, e.g. living in areas with elevated air pollution, and examine the lifestyle factors which may be protective. Protective lifestyle factors may be modifiable by the individual and may represent a means to improve environmental... more »

outcomes of interest: decision-making by parents regarding pregnancy termination or continuation, fetal/newborn outcomes (survival, NICU intervention, pain), decision-making by parents after birth, coping by parents and siblings

Management of heart failure involves attention to salt/fluid intake, control of blood pressure, and daily weight monitoring. Physical activity has been shown to reduce hospitalizations in patients with reduced cardiac function and it may also play a role in diastolic heart failure. Recording data on home-measured parameters and linking them to cardiac outcomes will provide information on optimal methods for use of mobile... more »